Results 111 to 120 of about 2,982,530 (319)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

On the breaking of collinear factorization in QCD

, 2012
We investigate the breakdown of collinear factorization for non-inclusive observables in hadron-hadron collisions. For pure QCD processes, factorization is violated at the three-loop level and it has a structure identical to that encountered previously ...
A Banfi, Andrzej Siódmok, CF Berger, E Gardi, G Oderda, J Keates, JC Collins, Jeffrey R. Forshaw, JR Forshaw, JR Forshaw, JR Forshaw, LJ Dixon, LJ Dixon, M Dasgupta, MH Seymour, MH Seymour, Michael H. Seymour, N Kidonakis, S Catani, S Catani, SM Aybat, T Becher, T Becher, V Duca Del   +23 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Exchange anisotropy, disorder and frustration in diluted, predominantly ferromagnetic, Heisenberg spin systems

, 2003
Motivated by the recent suggestion of anisotropic effective exchange interactions between Mn spins in Ga$_{1-x}$Mn$_x$As (arising as a result of spin-orbit coupling), we study their effects in diluted Heisenberg spin systems.
A. Oiwa, A.A. Burkov, A.L. Chudnovskiy, B. Beschoten, Chenggang Zhou, D.J. Priour, G. Alvarez, G. Zarand, G.A. Fiete, H. Ohno, J. Schliemann, K. Binder, K. Sato, K.C. Ku, K.M. Yu, K.W. Edmonds, L. Brey, M. Berciu, M. Berciu, M. Mayr, M.J. Calderón, M.P. Kennett, M.P. Kennett, Malcolm P. Kennett, Mona Berciu, N. Theodoropoulou, N. Theodoropoulou, R. N. Bhatt, R. Omari, R.G. Brown, R.N. Bhatt, R.N. Bhatt, R.N. Bhatt, S. Cho, S. Das Sarma, S.-R. Eric Yang, S.J. Potashnik, T. Dietl, Xin Wan, Y. Miyatake   +39 more
core   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Effect of Azospirillum brasilense in gas exchanges and production of soybean

Technology in Agronomy
The present study aimed to verify the photosynthetic responses and yield of soybean cultivars in relation to foliar inoculation with Azospirillum brasilense at different sowing dates.
Evandro Reina, Joênes Mucci Peluzio, Alessandra Maria de Lima Naoe, Fábio Josias Farias Monteiro   +3 more
doaj   +1 more source

Territoriality in educational settings : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Education [PDF]

, 1971
The concern of this thesis was territorial behaviours in classroom settings, namely: 1. The teacher's use of geographic space, and 2. Verbal interaction patterns resulting from teacher - pupil exchanges.
Hulbert, Murray Edwin
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source