Results 101 to 110 of about 48,655 (322)

Preparation of risedronate nanoparticles by solvent evaporation technique [PDF]

, 2014
One approach for the enhancement of oral drug bioavailability is the technique of nanoparticle preparation. Risedronate sodium (Biopharmaceutical Classification System Class III) was chosen as a model compound with high water solubility and low ...
Devínsky, Ferdinand, Dědková, Kateřina, Jampílek, Josef, Peikertová, Pavlína, Pisárčik, Martin, Plachá, Daniela, Vaculíková, Eliška   +6 more
core   +2 more sources

Addressing Small Data Challenges in Biopharmaceutical Development and Manufacturing: A Mini Review of Multi‐Fidelity Techniques

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The growing demand for biopharmaceutical products reflects their effectiveness in medical treatments. However, developing new biopharmaceuticals remains a major bottleneck, often taking up to a decade before market approval. Machine learning (ML) models have the potential to accelerate this process, but their success depends on access to large
Mohammad Golzarijalal, Uwe Aickelin, Ellen Otte   +2 more
wiley   +1 more source

The Molecular Chaperone α-Crystallin as an Excipient in an Insulin Formulation [PDF]

, 2010
PURPOSE: To investigate insulin fibrillation under accelerated stress conditions in the presence of a novel excipient, the molecular chaperone α-crystallin, in comparison with common excipients. METHODS: To induce fibrillation, recombinant human insulin (
Marco van de Weert, Ruedeeporn Tantipolphan, Tue Rasmussen, Wim Jiskoot   +3 more
core   +2 more sources

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

BMEMat, EarlyView.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu, Nan Xu, Xin Li, Xiaowo Kang, Tieyuan Bian, Junsheng Lin, Hao Tang, Yinyin Bao, Lu Zhang, Hongyan Yuan, Mingxi Yao, Xingyu Jiang, Zhi Luo   +12 more
wiley   +1 more source

Development and evaluation of a novel, multifunctional, coprocessed excipient via roller compaction of α-Lactose Monohydrate and Magnesium Silicate

Journal of Excipients and Food Chemicals, 2016
This study investigates co-processing lactose with synthetic amorphous magnesium silicate with the aim of expanding the use of directly compressible excipients based on native lactose. The co-processing was performed using roller compaction.
Faisal Al-Akayleh, Mustafa AL-Mishlab, Mohammed Shubair, Hatim S. AlKhatib, Iyad Rashid, Adnan Badwan   +5 more
doaj  

Optimisation of the Photostimulated Luminescence (PSL) Tests to Detect Irradiated Dietary Supplements: Experimental Studies of Pre-Concentration, Depletion Rate Analysis and Multiwavelength PSL Analysis [PDF]

, 2009
No abstract ...
Carmichael, L., Fisk, S., Sanderson, D.
core  

Linear cyclodextrin polymer prodrugs as novel yherapeutics for Niemann-Pick type C1 disorder [PDF]

, 2018
Niemann-Pick Type C1 disorder (NPC) is a rare lysosomal storage disease characterized by the accumulation of cholesterol in lysosomes. NPC has no FDA approved treatments yet, however 2-hydroxypropyl-β-cyclodextrin (HPβCD) has shown efficacy for treating ...
Aditya Kulkarni, Alberto Macone, Atul Dolas, Jessica Dragotto, Maria Teresa Fiorenza, Paola Caporali, Ramesh Jayaraman, Sandeep Goyal, Soniya Johny   +8 more
core   +1 more source

Eudragit®‐engineered pH‐responsive probiotic microspheres with enhanced gastrointestinal resistance and prolonged storage stability for inflammatory bowel disease therapy

BMEMat, EarlyView.
This study reports the development of AMS@Eud core‐shell microspheres, combining calcium alginate and pH‐responsive Eudragit® L100, which exhibit exceptional gastrointestinal resistance and long‐term storage stability (only 5.28%–9.09% viability loss over 35 days at 4–25°C), and effectively alleviate inflammatory bowel disease via gut microbiota ...
Ming Teng, Xiaomin Luo, Peng Zhang, Chen Yang, Yuniel Ma, Xinhua Liu   +5 more
wiley   +1 more source

Investigation of drug distribution in tablets using surface enhanced Raman chemical imaging [PDF]

, 2013
This paper reports the first application of surface enhanced Raman chemical imaging on pharmaceutical tablets containing the active ingredient (API) in very low concentrations.Taking advantage of the extremely intensive Raman signals in the presence of ...
Farkas, Attila, Farkas, István, Firkala, Tamás, Marosi, György, Vajna, Balázs   +4 more
core   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source