Results 141 to 150 of about 1,896,759 (248)
La lucha de las mujeres en América Latina: feminismo, ciudadanía y derechos
Palobra, 2007 Este articulo explora los diversos discursos generados acerca de las mujeres, del feminismo y del sufragismo en los años que se suceden desde los albores de las primeras reivindicaciones feministas hasta la época en que finalmente las organizaciones ...
Gloria Estela Bonilla Vélez
doaj
Análisis de los factores de exclusión social
, 2005 En este documento de trabajo se presenta el fenómeno de la exclusión social, identificando los factores que intervienen en él y el grado en que lo hacen.
Subirats Humet, Joan +2 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Cuaderno Urbano, 2010 Con base en el estudio de la vivencia y su circulación a partir de las narrativas locales, abordadas desde la relación entre experiencia y etnografía, miembros del barrio Los Pinos nos develan los dramas sociales que se han suscitado en su comunidad ...
Teresa Ontiveros Acosta
doaj
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
La exclusión infantil: ¿por qué la exclusión de los niños no tiene interés para la política?
, 2015 This article analyses the situation of child exclusion in Spain. The conceptof child exclusion is studied in more detail from the perspective of children´s well-being.
Uroz Olivares, Jorge
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source