Results 181 to 190 of about 1,830,322 (200)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Peer Attachment and Prosocial Behavior: The Mediating Role of Positive Legal Emotion and the Moderating Effect of Social Exclusion. [PDF]

Behav Sci (Basel)
Sun W, Xu S.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Immortal time bias from conditioning on future events in Parkinson's disease survival analysis. [PDF]

NPJ Parkinsons Dis
Viuff JH.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Sensitivity of Convergent Cross Mapping to temporal discontinuities: A case study of seasonal influenza in Hong Kong. [PDF]

Infect Dis Model
He L, He D.
europepmc   +1 more source

Childhood attention deficit hyperactivity disorder traits, societal exclusion and midlife psychological distress. [PDF]

Nat Ment Health
John A, O'Nions E, Corrigan L, Cotton J, Donnellan WJ, Nimmons D, Shelford H, Eshetu A, Saunders R, El Baou C, Stewart GR, Cheung RW, Desai R, McKechnie DG, Suh JW, Mandy W, Gaysina D, Pavlopoulou G, Asherson P, Agnew-Blais J, Stott J.   +20 more
europepmc   +1 more source

Organized community sport participation for children and youth with physical disability: A scoping review protocol. [PDF]

PLoS One
Davies K, Barran M, Pawliuk C, Choi T, Schilbach Pizzutto B, Lai K, Moreno Grangeiro P, Pollock CL.   +7 more
europepmc   +1 more source