Results 171 to 180 of about 565,650 (262)

Peer Attachment and Prosocial Behavior: The Mediating Role of Positive Legal Emotion and the Moderating Effect of Social Exclusion. [PDF]

Behav Sci (Basel)
Sun W, Xu S.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Pobreza, exclusión y política social

Pocos documentos en los últimos tiempos han logrado dar una visión de conjunto de la pobreza mundial y de las estrategias adoptadas para su reducción, como el publicado en 1996 por la Agencia Sueca para el Desarrollo y la Cooperación Internacional -SIDA-

core  

Sharing for the common good: Children's levels of social inclusion within the group and their sharing decisions in a public goods game. [PDF]

Br J Soc Psychol
Malin Y, Sabato H.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Cured but not healed: the mental health crisis in leprosy we continue to ignore. [PDF]

BMC Glob Public Health
Fastenau A, Asboeck A, Egbule D, Garimo IA, Schlumberger F, Ebrahimi H.   +5 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Research on the intervention mechanism and dynamic evolution of the digital divide's impact on the physical and mental health of older adults: a system dynamics perspective. [PDF]

Front Public Health
Shao T, Chen Y, Ren B, Gang S.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Defending and including students with special educational needs: a qualitative study with Chilean students. [PDF]

Front Psychol
Cuadra-Martínez D, Monárdez-Monárdez M, Espinosa-Caicedo J, Pérez-Zapata D, Sandoval-Díaz J, Landabur R, Castro-Carrasco P, Vera-Calzaretta A.   +7 more
europepmc   +1 more source