Results 41 to 50 of about 7,874,399 (296)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Critical role of the right VLPFC in emotional regulation of social exclusion: a tDCS study
Social Cognitive and Affective Neuroscience, 2018 There is abundant evidence suggesting that the right ventrolateral prefrontal cortex (rVLPFC) plays an important role in down-regulating the emotional response to social exclusion.
Zhenhong He +5 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Exclusión social: fundamentos teóricos y de la intervención
Global Social Work, 2013 La sociedad postindustrial ha traído consigo un nuevo orden social y la aparición de nuevas expresiones para definir y categorizar sus consecuencias sociales, entre ellas la que conocemos como exclusión social.
Ana Sánchez-Alías +1 more
doaj +1 more source
Older adults’ perceived sense of social exclusion from the digital world
Educational Gerontology, 2018 A great deal of information and many services can now be accessed digitally. In order to make use of such services, however, it is necessary to have some form of Internet access.
A. Seifert +2 more
semanticscholar +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Acompañar los procesos de inclusión social. Del análisis de la exclusión a la intervención social
Trabajo Social, 2014 La intervención social necesita criterios profesionales asentados en investigación social que aporten instrumentos técnicos y cientícos. En este artículo se presenta la metodología del acompañamiento para trabajar con personas en situación de exclusión ...
Esther Raya Diez +1 more
doaj
Measuring social exclusion in healthcare settings: a scoping review
International Journal for Equity in Health, 2018 BackgroundSocial exclusion is a concept that has been widely debated in recent years; a particular focus of the discussion has been its significance in relation to health.
P. O’Donnell +2 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source