Results 271 to 280 of about 190,541 (353)

AI cancer driver mutation predictions are valid in real-world data. [PDF]

Nat Commun
Tran TN, Fong C, Pichotta K, Luthra A, Shen R, Chen Y, Waters M, Kim S, Li X, de Bruijn I, Riely G, Berger MF, Ladanyi M, Chakravarty D, Schultz N, Jee J.   +15 more
europepmc   +1 more source

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source

KMT2A alterations in acute myeloid leukemia: a proposed genetic risk model and transplantation outcomes. [PDF]

Exp Hematol Oncol
Chen L, Li J, Zhu Y, Weng X, Huang Y, Zhao L, Yang G, Huang T, An R, Liu Z, Xu X, Chen Y, Huang Q, Wang K, Zhang S.   +14 more
europepmc   +1 more source

Variables influencing on the behavior of exclusive breastfeeding up to six months

, 2013
William Cáceres Fernández, Marlene de la Caridad Reyes Santana, Ernesto Malpica Alonso, Liuva Álvarez Alonso, Liliet Solís Molinet   +4 more
openalex   +1 more source

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Reply to Letter Regarding the Article "Safety and Efficacy of Moderate- vs. High-Intensity Statin Therapy after Nontraumatic Intracerebral Hemorrhage: A Real-World Evidence Analysis".

Cerebrovasc Dis
AbuAlrob M, Abdellatif R.
europepmc   +1 more source

Enumeration Comparison Study of BACARA® 2 and RAPID'B. cereus® Agars to Mannitol-Egg Yolk-Polymyxin (MYP) Agar for Detection of Bacillus cereus Group Strains. [PDF]

J AOAC Int
Cao G, Miller J, Wang SS, Tallent S.
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Off-label use of medications in psychiatry: the need and the caveats. [PDF]

World Psychiatry
Vieta E.
europepmc   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source