Results 41 to 50 of about 468 (174)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş +5 morewiley +1 more sourceReconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...Lukas Drexler, Markus R. Busch, Reinhard Sterner +2 morewiley +1 more sourceCell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis +10 morewiley +1 more sourceSearch for an invisibly decaying Higgs boson or dark matter candidates produced in association with a $Z$ boson in $pp$ collisions at $\sqrt{s} =$ 13 TeV with the ATLAS detector [PDF]
, 2017 A search for an invisibly decaying Higgs boson or dark matter candidates produced in association with a leptonically decaying $Z$ boson in proton--proton collisions at $\sqrt{s} =$ 13 TeV is presented. This search uses 36.1 fb$^{-1}$ of data collected by M. Aaboud, A. Kupco, P. Davison, S. Webb, S. Sekula, J. Huston, K. Jakobs, M. Spousta, M. Cobal, T. Agatonović-Jovin, J. Schovancová, M. Homann, P. Laurelli, A. Bassalat, P. Newman, M. Melo, M. Shapiro, S. Radhakrishnan, T. Eifert, N. Ozturk, S. Kuday, F. Legger, M. Sioli, H. Herr, S. P. Lopez, N. Bruscino, F. Giorgi, S. Robertson, F. Monticelli, A. Snesarev, L. Rotonda, D. Duschinger, E. Carquin, Mario Martínez, S. Crépé-Renaudin, W. Balunas, Y. Tikhonov, M. K. Ayoub, David Miller, Yanlin Liu, P. Mastrandrea, S. J. Batista, W. Leight, A. Colijn, M. G. Ratti, Liaoshan Shi, M. E. Nelson, Z. Barnovska-Blenessy, E. Kluge, J. Ocariz, Daniela Bortoletto, A. Lankford, N. Sinev, S. Tapprogge, O. Røhne, T. Masubuchi, D. E. F. Lima, Shenjian Chen, T. Martin, J. Poveda, E. Mountricha, T. N. Manh, M. Ouchrif, K. Korcyl, C. Grefe, K. Toms, P. Tipton, F. Klitzner, A. Valero, F. Mueller, T. Kishimoto, A. Vartapetian, K. Kawagoe, A. Barton, R. Sandbach, A. Policicchio, E. Yigitbasi, R. Schamberger, S. Karpov, P. Strizenec, A. Antonov, C. Lester, D. Casper, J. Navarro, B. Micco, S. Koperny, J. Strandberg, B. A. Long, C. Bertella, P. Schwemling, M. Vos, E. Meoni, T. Holmes, A. Zaman, K. Meier, C. Doglioni, L. Vigani, A. Boldyrev, J. Searcy, J. Stark, E. Yatsenko, R. Peschke, M. Kuze, B. Hooberman, A. Ferrari, D. Scannicchio, D. Costanzo, J. Penwell, M. Fenton, A. Klimentov, S. P. Griso, B. Ristić, I. Panagoulias, R. Blair, S. Schaetzel, J. Long, T. Kuhl, G. Gustavino, M. Dyndał, M. Antonelli, B. Malaescu, K. Grimm, L. P. Rodriguez, M. Köhler, A. Horton, A. Ezhilov, M. Arratia, A. Bellerive, J. Masik, A. Loesle, M. Janus, J. Kirk, S. Kama, G. Iacobucci, R. T. Roberts, E. Shulga, B. Gorini, Xueyao Zhang, M. Hagihara, J. Butler, H. Fox, S. Grancagnolo, E. Koffeman, M. Beattie, S. Pino, N. Madysa, K. Black, G. Hallewell, L. Franconi, D. Fassouliotis, J. Smith, A. Tricoli, M. Dumancic, H. Iwasaki, M. Kuna, M. Giannelli, B. Stapf, S. Dita, T. Cao, Michela Paganini, V. Ellajosyula, I. Pogrebnyak, E. Petit, W. Hopkins, J. Faltova, S. Raddum, M. Mantoani, Y. Chiu, Wenzhong Guo, S. Swift, E. Lipeles, M. Venturi, M. Nedden, A. Ducourthial, S. Artz, M. Oreglia, H. Neal, E. Drechsler, K. Einsweiler, F. Lorenzi, S. Giagu, E. Kneringer, O. Arslan, B. Freund, B. Girolamo, H. Yildiz, D. Whiteson, A. Dewhurst, K. Shaw, Yingchun Zhu, S. Maeland, C. Young, N. Biesuz, J. Terron, P. Urquijo, W. Taylor, V. C. Gimenez, N. Kanaya, T. Barillari, T. Neep, F. Peri, G. Conti, P. Clark, S. Schier, K. Vorobev, J. Hrivnac, M. Barisits, T. Kunigo, A. Grillo, S. Camarda, I. Ueda, D. Maximov, R. Kopeliansky, N. Konstantinidis, O. Jinnouchi, H. Sadrozinski, V. Kazanin, E. Barberio, K. Tackmann, B. Tannenwald, H. Schulz, R. Kass, M. Sutton, T. Ženiš, M. Hoeferkamp, L. Dell’asta, V. Wallangen, Fangzhou Zhang, M. Vincter, S. Sivoklokov, G. Herten, V. Nikolaenko, D. Kirchmeier, C. Chau, A. Girolamo, A. O'Rourke, N. Abraham, M. Nomachi, M. Elsing, C. Geng, K. Mochizuki, A. Ciaccio, B. Burghgrave, A. S. Mete, M. Stoebe, H. Kucuk, Hongbin Liu, F. Corriveau, I. Bloch, K. Smolek, R. Brenner, P. Tas, H. Graaf, G. Marceca, B. Petersen, V. Solovyev, B. Haney, S. Gonzalez-Sevilla, C. Shimmin, P. Werner, P. Schacht, N. Whallon, A. Negri, S. Farrington, P. Dita, M. Villa, V. Cindro, A. Minaenko, S. Honda, K. Wong, X. Ruan, P. F. Salvatore, K. Hamacher, B. Mansoulie, Yang Qin, C. Leggett, J. Mansour, B. Allbrooke, S. Hageböck, C. Ferretti, D. Biedermann, J. Kroll, E. Gkougkousis, H. Torre, T. Heim, S. Shimizu, S. Fracchia, F. Tresoldi, S. Che, S. Oda, C. Gatti, C. Gutschow, M. Saito, F. L. Sterzo, T. Åkesson, J. Vossebeld, J. Moss, M. Dunford, J. Taenzer, A. Kowalewska, Kyungeon Choi, S. Harkusha, P. Saha, G. Gach, M. Düren, S. Wahrmund, You Zhou, Matt Zhang, A. Olszewski, M. Biglietti, S. Jones, T. Jakoubek, S. Connell, A. Doria, S. Wang, F. Socher, M. Danninger, C. Blocker, S. Istin, E. Varnes, J. Hansen, M. Ghneimat, G. Iakovidis, A. Picazio, C. J. Treado, K. Nagai, Ye Chen, M. Ishitsuka, R. McCarthy, A. Salvo, A. Kourkoumeli-Charalampidi, F. Spettel, A. Gorišek, D. Gillberg, Y. Heng, P. Shatalov, Y. Smirnov, S. Majewski, K. Sliwa, K. Oussoren, A. Demilly, B. Wynne, P. Bechtle, M. Fiolhais, F. H. Phillips, F. Ito, P. Lösel, A. Alonso, Qing Wang, T. Guillemin, E. Winkels, J. J. Kempster, S. P. Yuen, Shuo Han, I. Maznas, M. Wobisch, K. Augsten, J. Burr, G. Stark, A. Nelson, E. Guirriec, K. Parker, N. Belyaev, A. Ryzhov, D. Moreno, F. Spanò, P. Deviveiros, Simon Lin, M. Stanitzki, C. Sandoval, B. King, K. Onogi, R. Falla, A. P. Pages, M. Begel, G. Forcolin, A. Mincer, Young-Kee Kim, L. Morvaj, E. Guido, R. Debbe, K. Belotskiy, A. Soukharev, P. Gemmeren, C. Agheorghiesei, R. Teuscher, A. Chuinard, R. Jansky, C. Roda, D. Quilty, A. Martyniuk, A. Undrus, B. Gjelsten, J. M. I. Ponce, D. Boscherini, L. Kashif, N. Semprini-Cesari, U. Bratzler, P. Fassnacht, K. Finelli, C. David, L. Zwalinski, M. A. Verzini, R. Kukla, R. Ströhmer, T. Stevenson, Jie Yu, P. Klimek, C. Galea, L. Heinrich, A. Zibell, C. Troncon, F. Guescini, D. Denysiuk, M. Kacimi, Chunhui Chen, A. Perez, S. Menke, Chao Wang, E. Shabalina, G. Unal, R. Gardner, A. Forti, Yu Zhang, M. Morii, I. Gorelov, T. Kosek, Zhiqin Zhang, C. Farina, T. Brooks, K. Sekhon, B. Tong, G. Chiodini, S. Weber, Jun Guo, L. Simić, N. Norjoharuddeen, A. Gabrielli, E. Akilli, M. Wessels, Liang Li, A. Schwartzman, D. Sosa, L. A. Bella, T. Honda, A. Strubig, A. Weidberg, J. J. Teoh, H. Potti, S. Snyder, U. Blumenschein, R. Konoplich, M. Javurkova, F. Hoenig, B. L. Clark, S. Turchikhin, J. Kvita, T. Klingl, V. Boisvert, B. Allen, G. Lerner, S. Veneziano, Y. Hasegawa, Y. Takubo, M. Huhtinen, A. Kiryunin, J. Fischer, A. Beddall, N. Kimura, S. Amoroso, Dengfeng Zhang, P. Gris, I. Gkialas, S. Smirnov, E. Rossi, M. Haleem, D. Froidevaux, R. Pezoa, B. Ali, F. Lyu, D. Emeliyanov, S. Kuehn, M. Lassnig, T. Pauly, A. Redelbach, H. Hakobyan, B. Wosiek, N. Bernard, A. Karyukhin, A. Mizukami, M. Kolb, L. Pontecorvo, T. Lenz, J. Butterworth, S. Stark, A. Korn, S. Henrot-Versillé, K. Todome, F. Dallaire, N. Kondrashova +499 moresemanticscholar +1 more sourceInterpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo +7 morewiley +1 more sourceUSP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra +16 morewiley +1 more sourceLongitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht +14 morewiley +1 more source
