Results 21 to 30 of about 1,393,348 (340)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Association between electronic cigarette use and tobacco cigarette smoking initiation in adolescents: a systematic review and meta-analysis

BMC Public Health, 2021
Background This systematic review of prospective longitudinal primary studies sought to determine whether electronic cigarette (e-cigarette) use by teenagers who had never smoked conventional tobacco cigarettes (tobacco cigarettes) at baseline was ...
Doireann O’Brien, Jean Long, Joan Quigley, Caitriona Lee, Anne McCarthy, Paul Kavanagh   +5 more
doaj   +1 more source

Public Welfare Foundation - 2002 Annual Report [PDF]

, 2003
Contains board chair and executive director's message, mission statement, program area and grant guidelines, financial statements, and lists of board members and ...

core  

(WP 2011-01) It Takes Two: The Incidence and Effectiveness of co-CEOs [PDF]

, 2011
This study examines the phenomenon of co-CEOs within publicly traded firms. Although shared executive leadership is not widespread, it occurs within some very prominent firms.
Adams, Aghion, Almazan, Alvarez, Anderson, Barnard, Bertrand, Boone, Brown, Chalmers, Coles, Core, Dahya, Dehejia, Denis, Drucker, Dunbar, Easterwood, Faleye, Fich, Gadhoum, Gompers, Hackman, Hermalin, Huson, Jensen, Kale, Kandel, Kothari, Malmendier, Mintzberg, O’Toole, Parrino, Patell, Pearce, Roll, Selznick, Shivdasani, Stein, Tichy, Wasserman, Weisbach   +41 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Abstracts of the Malaysian Medical Students Summit, 2015

International Journal of Medical Students, 2017
N ...
Executive Board of IJMS
doaj   +1 more source

Lloyd A. Fry Foundation - 2005 Annual Report [PDF]

, 2006
Contains mission statement, board chair's and executive director's messages, program information, grantee profiles, grants list, financial statements, grant guidelines, and lists of board members and ...

core  

Corporate boards, ownership structure and firm performance in an environment of severe political and economic crisis [PDF]

, 2010
This study examines the relationship between board and ownership structures and firm performance in an environment of severe political and economic crisis.
Adams, Addison, Agrawal, Aguilera, Ajinkya, Baek, Berglof, Blundell, Bozec, Burkart, Capezio, Chamisa, Chamisa, Claessens, Claessens, Coles, Core, Dahya, Daily, Daily, Dalton, Durnev, Elsayed, Fama, Filatotchev, Gourevitch, Gujarati, Haniffa, Hill, Ho, Hoskisson, Jensen, Joh, Karamanou, Klapper, Klein, Kohler, Kriger, La Porta, La Porta, Larcker, Linck, Lipton, Mangena, Mangena, Mitroff, Mitton, Okeahalam, Pagano, Pearson, Peasnell, Perrini, Ramdani, Roe, Roodman, Scott, Shleifer, Short, Vafeas, Weir, World Bank, Yermack   +61 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source