Results 121 to 130 of about 5,770,745 (393)

No effect of arm exercise on diaphragmatic fatigue or ventilatory constraint in Paralympic athletes with cervical spinal cord injury [PDF]

, 2010
Cervical spinal cord injury (CSCI) results in a decrease in the capacity of the lungs and chest wall for pressure, volume, and airflow generation. We asked whether such impairments might increase the potential for exercise-induced diaphragmatic fatigue ...
Baydur A, Borg G, Brown R, Bryan J. Taylor, Christopher R. West, Duffield D, Goldman JM, Green M, Lee M. Romer, Otis AB, Rodarte JR, Swain DP   +11 more
core   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The influence of voluntary upper body exercise on the performance of stimulated paralysed human quadriceps [PDF]

, 1997
In this study the influence of voluntary upper body exercise on the performance of stimulated paralysed human quadriceps was investigated in five subjects with spinal cord lesions in the thoracic spine.
Boom, H.B.K., Franken, H.M., Franken, Henry M., IJzerman, Maarten Joost, Veltink, Petrus H., Withaar, Frank S.   +5 more
core   +4 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Methodological and conceptual limitations in exercise addiction research [PDF]

, 2015
The aim of this brief analytical review is to highlight and disentangle research dilemmas in the field of exercise addiction. Research examining exercise addiction is primarily based on self-reports, obtained by questionnaires (incorporating ...
Attila Szaboa, Barbara Mervód, Mark D. Griffithsb, Ricardo La, Vega Marcosc, Zsolt Demetrovicsd   +5 more
core   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Exercise-induced respiratory muscle fatigue: implications for performance [PDF]

, 2008
It is commonly held that the respiratory system has ample capacity relative to the demand for maximal O-2 and CO2 transport in healthy humans exercising near sea level.
Polkey, MI, Romer, LM
core   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Exploring the feasibility, sustainability and the benefits of the GrACE + GAIT exercise programme in the residential aged care setting [PDF]

, 2019
Fien, S ORCiD: 0000-0003-0181-5458Background: The feasibility and benefits of a 24-week targeted progressive supervised resistance and weight-bearing exercise programme (Group Aged Care Exercise + GAIT (GrACE + GAIT)) in the residential aged care (RAC ...
Climstein, Mike, Fien, Samantha, Henwood, Tim, Keogh, Justin W L, Rathbone, Evelyne   +4 more
core   +2 more sources

Exercise for preventing falls in older people living in the community.

Cochrane Database of Systematic Reviews, 2016
BACKGROUND At least one-third of community-dwelling people over 65 years of age fall each year. Exercises that target balance, gait and muscle strength have been found to prevent falls in these people. An up-to-date synthesis of the evidence is important
C. Sherrington, N. Fairhall, Geraldine Wallbank, A. Tiedemann, Zoe A Michaleff, K. Howard, L. Clemson, Sally Hopewell, S. E. Lamb   +8 more
semanticscholar   +1 more source