Results 151 to 160 of about 4,230,796 (390)

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Glutamine Supplementation: A Possible Strategy to Help Mitigate Health Risks of Heat-Related Illness

open access: yesJournal of Nutrition and Metabolism
A rise in body temperature caused by physical work, including exercise, in a hot climate can lead to heat-related illnesses such as exertional heat exhaustion and stroke.
Micah Zuhl   +3 more
doaj   +1 more source

Interaction of external, introjected, and identified regulation with intrinsic motivation in exercise: Relationships with exercise enjoyment [PDF]

open access: yes, 2005
The present study examined the way in which the exercise-related motives of external regulation, introjected regulation, and identified regulation interacted with intrinsic motivation to relate to exercise enjoyment.
Karageorghis, CI, Vlachopoulos, SP
core  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Pricing American Options by Exercise Rate Optimization [PDF]

open access: yesarXiv, 2018
We present a novel method for the numerical pricing of American options based on Monte Carlo simulation and the optimization of exercise strategies. Previous solutions to this problem either explicitly or implicitly determine so-called optimal exercise regions, which consist of points in time and space at which a given option is exercised. In contrast,
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

THE EFFECT OF EXERCISE ON RENAL PLASMA FLOW IN NORMAL MALE SUBJECTS [PDF]

open access: bronze, 1948
Carleton B. Chapman   +4 more
openalex   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

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