Results 151 to 160 of about 5,770,745 (393)

Promoting Team-Based Exercise Among African American Breast Cancer Survivors [PDF]

open access: yes, 2018
Physical activity benefits the health and well-being of breast cancer survivors (BCS). Yet, many African American survivors do not routinely exercise and have increased risk of poor outcomes.
Ng, Alexander V.   +4 more
core   +1 more source

Effect of aquatic exercise on mental health, functional autonomy, and oxidative dysfunction in hypertensive adults

open access: yesClinical and Experimental Hypertension, 2018
The aquatic exercise is an effective non-pharmacological therapy for prevention and control of hypertension. The objective of the present study was to investigate the effect of aquatic exercise on mental health, functional autonomy, and oxidative ...
Luciano Acordi Da Silva   +8 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Advancing Objective Mobile Device Use Measurement in Children Ages 6–11 Through Built-In Device Sensors: A Proof-of-Concept Study

open access: yesHuman Behavior and Emerging Technologies
Mobile devices (e.g., tablets and smartphones) have been rapidly integrated into the lives of children and have impacted how children engage with digital media.
Olivia L. Finnegan   +12 more
doaj   +1 more source

Exercise and Depression

open access: yesEndocrinology and Metabolism, 2015
Depression is a chronic medical condition that can lead to serious functional impairment, morbidity, and mortality if left untreated [1,2]. Increasing awareness of depression as a significant public health problem has led to greater interest in both the underlying mechanisms and external factors associated with the disease, with therapies developed to ...
openaire   +4 more sources

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Relative and absolute intensity accelerometer metrics decipher the effects of age, sex, and occupation on physical activity

open access: yesBMC Public Health
Background To investigate whether quantifying both the absolute and relative intensity of physical activity (PA) improves understanding of age, sex, and occupation-related differences in PA in healthy adults aged 20–89.
Fabian Schwendinger   +7 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

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