Results 151 to 160 of about 4,574,452 (297)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Use of the Omnipod 5 Automated Insulin Delivery System Activity Feature Reduces Insulin Delivery and Attenuates the Drop in Glycemia Associated With Exercise in a Randomized Controlled Trial. [PDF]

Diabetes Care
Turner LV, Sherr JL, Zaharieva DP, Baran J, Hirsch IB, Bode BW, Brown SA, Bzdick S, Church MM, Hansen DW, Kingman R, Laffel LM, Shah VN, Stone S, Vienneau TE, Huyett LM, Dumais B, Ly TT, Riddell MC, Omnipod 5 Exercise Research Group .   +19 more
europepmc   +1 more source

Muscular exercise, lactic acid, and the supply and utilisation of oxygen. Part IX. —Muscular activity and carbohydrate metabolism in the normal individual

, 1925
K. Furusawa
openalex   +1 more source

CHANGES IN THE BLOOD AND CIRCULATION WITH CHANGES IN POSTURE. THE EFFECT OF EXERCISE AND VASODILATATION [PDF]

, 1935
John B. Youmans, Joseph H. Akeroyd, Helen Frank   +2 more
openalex   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Myopathic Symptoms and Exercise Tolerance in Adolescent Patients With Long-Chain Fatty Acid Oxidation Disorders. [PDF]

J Inherit Metab Dis
Schwantje M, van Brussel M, Takken T, de Sain-van der Velden MGM, Langeveld M, Visser G, Fuchs SA.   +6 more
europepmc   +1 more source

THE INFLUENCE OF CHILLING AND EXERCISE ON FREE AMINO ACID CONCENTRATIONS IN RAT TISSUES

, 1950
John Williams, Paul E. Schurr, C.A. Elvehjem   +2 more
openalex   +1 more source

Urinary output of creatine and creatinine associated with physical exercise, and its relationship to carbohydrate metabolism [PDF]

, 1939
W. Hobson
openalex   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

The effect of exercise on menstrual symptoms: a randomized controlled trial. [PDF]

BMC Womens Health
Koçak M, Şevgin Ö.
europepmc   +1 more source