Results 161 to 170 of about 5,869,609 (392)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Advancing Objective Mobile Device Use Measurement in Children Ages 6–11 Through Built-In Device Sensors: A Proof-of-Concept Study

Human Behavior and Emerging Technologies
Mobile devices (e.g., tablets and smartphones) have been rapidly integrated into the lives of children and have impacted how children engage with digital media.
Olivia L. Finnegan, R. Glenn Weaver, Hongpeng Yang, James W. White, Srihari Nelakuditi, Zifei Zhong, Rahul Ghosal, Yan Tong, Aliye B. Cepni, Elizabeth L. Adams, Sarah Burkart, Michael W. Beets, Bridget Armstrong   +12 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Progressive statistics for studies in sports medicine and exercise science.

Medicine & Science in Sports & Exercise, 2009
W. Hopkins, S. Marshall, A. Batterham, J. Hanin   +3 more
semanticscholar   +1 more source

Relative and absolute intensity accelerometer metrics decipher the effects of age, sex, and occupation on physical activity

BMC Public Health
Background To investigate whether quantifying both the absolute and relative intensity of physical activity (PA) improves understanding of age, sex, and occupation-related differences in PA in healthy adults aged 20–89.
Fabian Schwendinger, Raphael Knaier, Jonathan Wagner, Denis Infanger, Eric Lichtenstein, Timo Hinrichs, Alex Rowlands, Arno Schmidt-Trucksäss   +7 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Glutamine Supplementation: A Possible Strategy to Help Mitigate Health Risks of Heat-Related Illness

Journal of Nutrition and Metabolism
A rise in body temperature caused by physical work, including exercise, in a hot climate can lead to heat-related illnesses such as exertional heat exhaustion and stroke.
Micah Zuhl, Jonathan Specht, Sage Beatty, Christine Mermier   +3 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Determination of moderate walking intensity using step rate and VO2 reserve in healthy men

BMC Public Health
Objective This study investigated step rates (SR) during overground walking to estimate the relative aerobic capacity that corresponds to a moderate intensity.
Woo Ram Bae, Yongsuk Seo, Somi Yun, Dae Taek Lee   +3 more
doaj   +1 more source