Results 191 to 200 of about 1,011,914 (266)

An overview of current research on exercise interventions in aging and aging-related disease. [PDF]

Front Aging
Jain A, Johnston C, Zhang Y, Oh J, Tsung C, Kent E, Zhang H.   +6 more
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Exploring Long-Term Exercise and Fitness Maintenance Using Group Versus Individual Training in a Diverse Group of Breast Cancer Survivors. [PDF]

Healthcare (Basel)
Merifield L, Toyama M, Gooman A, Teranishi-Hashimoto C, Lim E, Yamada PM, Fukui JA.   +6 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Molecular pathways linking traumatic brain injury to cardiovascular dysfunction: therapeutic potential of physical exercise. [PDF]

Metab Brain Dis
Feiteiro LMS, Alchieri EF, Godinho DB, Dal Magro G, Torbes J, Cardozo DM, de Mattos Mautone Pedroso JV, Furian AF, Oliveira MS, Fighera MR, Royes LFF.   +10 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The Effect of High-Intensity Interval Training and Mixed Probiotic Supplementation on SMOC-1 Gene Expression, Insulin Resistance, and Blood Glucose in Male Rats With Induced Diabetes

Journal of Diabetes Research
Dorsa Ghazvineh, Marjan Dodangeh, Sahar Razmjou, Alireza Rahimi, Mitra Azizi Masouleh   +4 more
doaj   +1 more source

Effects of a 4-Week Multi-Exercise Isometric Resistance Training Programme on Resting and Ambulatory Blood Pressure in Normotensive Adults. [PDF]

Eur J Sport Sci
Wright BH, Antrobus MR, Jones PGW, Baross AW.   +3 more
europepmc   +1 more source