Results 221 to 230 of about 5,869,609 (392)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice [PDF]

open access: gold, 2019
Jaime M. Ross   +6 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Brazilian nephrologist's knowledge of intradialytic exercise: a national survey. [PDF]

open access: yesJ Bras Nefrol
Cordeiro MDNA   +5 more
europepmc   +1 more source

Exercise Intensity as a Determinant of Exercise Induced Hypoalgesia

open access: yes, 2011
The purpose of this study was to examine pain perception during and following two separate 30-min bouts of exercise above and below the Lactate Threshold (LT).
Drury, Daniel G., Wonders, Karen Y.
core  

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