Results 121 to 130 of about 3,858,405 (306)

Distinct gut microbiome signatures associated with sedentary behavior improvement following rehabilitation in chronic obstructive pulmonary disease patients with higher functional exercise capacity

Scientific Reports
Chronic obstructive pulmonary disease (COPD) is associated with reduced functional exercise capacity and increased sedentary behavior, both of which worsen prognosis. Although rehabilitation is a standard intervention, its impact on physical activity and
Hiroki Tashiro, Yuki Kuwahara, Yuki Kurihara, Yoshie Konomi, Koichiro Takahashi   +4 more
doaj   +1 more source

Unveiling Functional Impairment in Fabry Disease: The Role of Peripheral vs. Cardiac Mechanisms

Biomedicines
Background: Anderson–Fabry disease (AFD) is a progressive lysosomal storage disorder characterized by systemic glycosphingolipid accumulation. While cardiac imaging plays a central role in disease monitoring, the relationship between structural ...
Geza Halasz, Chiara Lanzillo, Raffaella Mistrulli, Emanuele Canali, Elisa Fedele, Paolo Ciacci, Federica Onorato, Guido Giacalone, Giovanni Nardecchia, Domenico Gabrielli, Federica Re   +10 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Illustrative Quotes, Interview Guide and Information Sheets for: Developing laboratory capacity for Good Laboratory Practice certification: lessons from a Tanzanian insecticide testing facility

Interview guide used across 5 test facilities in 3 African countries to explore enablers, barriers and effects of a research capacity strengthening programme, targeting development of a Quality Management System compliant with Good Laboratory Practice ...
Capacity Research, Centre for
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Correlation of exercise capacity with skeletal muscle strength, pulmonary and cardiac autonomic functions in postmenopausal women

Bulletin of Faculty of Physical Therapy
Objectives The purpose of the study was to investigate the association of the major systems, i.e., musculoskeletal, pulmonary, and cardiac autonomic systems of the body, with exercise capacity among post-menopausal women.
Manisha Verma, Minaxi Saini
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Age-specific determinants of reduced exercise capacity in youth after heart transplant: A longitudinal cohort study

JHLT Open
Background: Although prior studies show that children have impaired exercise capacity after heart transplant, the age-specific determinants of this phenomenon are not well understood.
N.D. Markiewitz, MD, MA, M. Lane-Fall, MD, MSHP, J. Huang, PhD, L. Mercer-Rosa, MD, MSCE, K. Stack, MD, J. Mitchell, PhD, M.J. O’Connor, MD, J.W. Rossano, MD, MS, S. Paridon, MD, D.S. Burstein, MD, MSCE, J.B. Edelson, MD   +10 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Exercise-induced oxyhaemoglobin desaturation, ventilatory limitation and lung diffusing capacity in women during and after exercise

, 2002
Arterial haemoglobin saturation during exercise in healthy young women [eight subjects mean (SEM) age 20.8 (1.8) years] was measured to confirm the theory that young women experience exercise-induced arterial hypoxaemia (EIAH) at a lower relative ...
Justin Walls (14752048), Wood-Baker, R (15478649), Stedman, W (15492482), Maskrey, M (15476975)   +3 more
core