Results 151 to 160 of about 3,858,405 (306)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Reduction of exercise capacity in sarcoidosis in relation to disease severity

, 2015
Anastasios Kallianos,1 Paul Zarogoulidis,2 Fotini Ampatzoglou,2 Georgia Trakada,2,3 Elias Gialafos,4 Georgia Pitsiou,2 Athanasia Pataka,2 Lemonia Veletza,2 Konstantinos Zarogoulidis,2 Wolfgang Hohenforst-Schmidt,5 Dimitris Petridis,6 Ioannis Kioumis,2 ...
Pataka A, Gialafos E, Ampatzoglou F, Kioumis I, Hohenforst-Schmidt W, Kallianos A, Trakada G, Rapti A, Pitsiou G, Veletza L, Zarogoulidis K, Petridis D, Zarogoulidis P   +12 more
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The relationship between exercise capacity and different functional markers in pulmonary rehabilitation for COPD

, 2018
Maria Kerti, Zsuzsanna Balogh, Krisztina Kelemen, Janos T Varga Department of Pulmonary Rehabilitation, National Koranyi Institute for Pulmonology, Budapest, Hungary Rationale: The relationship of functional parameters such as lung mechanics, chest ...
Kerti M, Kelemen K, Varga JT, Balogh Z
core  

Pulford Justin, Crossman Susie, Begg Sara, Amegee Quach Jessica, Abomo Pierre, El Hajj Taghreed and Bates Imelda, 2020, "Strengthening research management and support services in sub-Saharan African universities and research institutions - anonymous data extraction"

Intermediary data extracted from 28 research management system capacity assessment reports completed in 25 universities/research institutions from across 15 sub Saharan-African countries between 2014 and ...
Centre for Capacity Research
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Ivabradine Use and Exercise Capacity Post-Atrial Switch Repair for Transposition of Great Arteries. [PDF]

JACC Adv
Wilson WM, Burchill L, Finch S, Grigg L, Irving L, Harrington H, Zentner D, Cheung MMH.   +7 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source