Results 181 to 190 of about 10,216,930 (203)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

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Epigenetics in Exercise Science and Sports Medicine

Medical Epigenetics, 2021
A Schenk
exaly  

A Systematic Review of Rehabilitation and Exercise Recommendations in Oncology Guidelines

Ca-A Cancer Journal for Clinicians, 2021
Julie K. Silver, Nicole L Stout, Kathleen Doyle Lyons   +2 more
exaly  

Epigenetics in Exercise Science and Sports Medicine

Medical Epigenetics, 2016
Wilhelm Bloch, A Schenk
exaly  

Exercise Is Medicine in Oncology: Engaging Clinicians to Help Patients Move Through Cancer

Ca-A Cancer Journal for Clinicians, 2019
Catherine M Alfano, Lynn N Gerber, Andrea L Cheville   +2 more
exaly  

Exercise and Nutrition May Prolong the Lives of Patients With Colon Cancer

Ca-A Cancer Journal for Clinicians, 2018
Mike Fillon
exaly  

Effects of Acute Mental Stress and Exercise on T-Wave Alternans in Patients With Implantable Cardioverter Defibrillators and Controls

Circulation, 2004
Richard L Verrier, David S. Krantz, Willem J Kop   +2 more
exaly  

Shear Stress Mediates Endothelial Adaptations to Exercise Training in Humans

Hypertension, 2010
Nicola Hopkins, Ellen A Dawson, Dick H J Thijssen   +2 more
exaly