Results 141 to 150 of about 593,254 (265)

Cardiopulmonary Exercise Test in Heart Failure and the Benefits of Exercise and Rehabilitation-An Updated Review. [PDF]

Rev Cardiovasc Med
Sakellaropoulos SG, Mitsis A.
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Relationship between weight-carrying capacity and performance in a standardized treadmill exercise test in horses. [PDF]

Physiol Rep
Söderroos D, Stefánsdóttir GJ, Ragnarsson S, Gunnarsson V, Jansson A.   +4 more
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Cardiopulmonary exercise test variations in patients with a Fontan circulation: impact of fenestration patency and associations with clinical outcomes. [PDF]

Open Heart
Ortega-Aviles LM, Santos-Patarroyo SD, Opp DN, Cetta F, Egbe AC, Miranda WR, Allison TG.   +6 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Novel markers of myocardial recovery in patients with left ventricular assist device: A cardiopulmonary exercise test and hemodynamic analysis. [PDF]

JHLT Open
Soydara C, Giverts I, Griskowitz CL, Landsteiner I, Drezek K, Minasian A, Logan TL, Camuso J, Dempsey AE, Milley K, Osho AA, Michel E, Coglianese E, Mastoris I, D'Alessandro DA, Jurgens CY, Lewis GD, Ton VK.   +17 more
europepmc   +1 more source

A Case Report. Dizziness due to Vasovagal Reflex Diagnosed by an Exercise Test.

, 2000
Yoshio Masaki, Ichiro Ando, Masafumi Nakagawa, Hidenori Yokoi, Mariko Okugawa, Emi Higashiyama, Ginichiro Ichikawa   +6 more
openalex   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Which One Works Better? Testing Outcomes of Using a Somatosensory Game Intervention and a Chair-Based Exercise Program on Elderly

, 2013
I-Tsun Chiang, Mao Liua, Hsin-Chin Wu, Chi Yao Chang, Hsiu Chi Fu, Shang-Ti CHENA, Chien-Hsin Yeh   +6 more
openalex   +2 more sources