Results 141 to 150 of about 8,056,925 (296)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Tractor Testing; Belt Power Test; Massey Harris

open access: yes, 1948
"Test no. 401. Massey-Harris Pony. R. Valentine, H. Hartz, E. Dahl (factory representative), H. Mizner, V. Hitt." They are standing behind the Massey-Harris Pony tractor inside the tractor test lab.
Nebraska Tractor Test Laboratory
core   +1 more source

Exercise test is essential in LV-only fusion CRT pacing without right ventricle lead

open access: yesClinical Interventions in Aging, 2019
Cristina Vacarescu,1 Dragos Cozma,1,2 Lucian Petrescu,1,2 Simona Dragan,1,2 Cristian Mornos,1,2 Simina Crisan,1,2 Horea Feier,1,2 Mihai-Andrei Lazar,1 Ramona Alina Cozlac,1,2 Constantin Tudor Luca1,21Cardiology Department, Victor Babeș University of ...
Vacarescu C   +9 more
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Six-minute stepper test: a valid clinical exercise tolerance test for COPD patients

open access: yes, 2016
JM Grosbois,1,2 C Riquier,3 B Chehere,4 J Coquart,5 H Béhal,6 F Bart,2 B Wallaert,2,3 C Chenivesse3 1FormAction Santé, Pérenchies, France; 2Department of Respiratory Medicine, Centre Hospitalier Germon et Gauthier, Béthune ...
Coquart J   +7 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Test Track; Maintenance

open access: yes, 1970
Water wagon sprays the soil test area beside the concrete track. The disced ground alongside the track is sprayed with water. This is in preparation for some future special tests.
Nebraska Tractor Test Laboratory
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Tractor Testing; Belt Test; Allis Chalmers

open access: yes, 1948
Official belt test no. 397 Allis-Chalmers HD19." The Allis-Chalmers HD-19 crawler on berlt power test inside the tractor test lab. Technician Joe Flamm stands measuring belt speed with a hand-held tachometer.
Nebraska Tractor Test Laboratory
core  

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