Results 51 to 60 of about 16,395,796 (358)

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

ERS statement on standardisation of cardiopulmonary exercise testing in chronic lung diseases

European Respiratory Review, 2019
The objective of this document was to standardise published cardiopulmonary exercise testing (CPET) protocols for improved interpretation in clinical settings and multicentre research projects.
T. Radtke, Sarah Crook, G. Kaltsakas, G. Kaltsakas, Z. Louvaris, D. Berton, D. Urquhart, A. Kampouras, R. Rabinovich, S. Vergès, Dimitris Kontopidis, Jeanette Boyd, T. Tonia, D. Langer, J. Brandt, Y. Goërtz, C. Burtin, M. Spruit, M. Spruit, D. Braeken, S. Dacha, S. Dacha, F. Franssen, P. Laveneziana, E. Eber, T. Troosters, J. Neder, M. Puhan, R. Casaburi, I. Vogiatzis, I. Vogiatzis, H. Hebestreit   +31 more
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

What does the vibration therapy add?: a quasi-experimental, pilot study on the short term effects of whole-body vibration as mode of exercise for nursing home residents aged 80+ [PDF]

, 2018
Aims: To compare the responses of nursing home residents aged 80+ to an 8 weeks exercise program performed on a vibratory device and to the same exercise program preformed without vibration on lower limb performance, functional dependence and quality ...
Alfonso Rosa, Rosa Mª, Alfonso Rosa, Rosa Mª, Pozo Cruz, Jesús del, Álvarez Barbosa, Francisco   +3 more
core   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Exercise Stress Testing [PDF]

Medicine, 2002
Abstract Exercise ECG in the diagnosis of angina was first reported in 1932, and has since become central to the management of patients with suspected or proven coronary artery disease. This contribution focuses on performing the test and its interpretation.
openaire   +1 more source

Interaction of external, introjected, and identified regulation with intrinsic motivation in exercise: Relationships with exercise enjoyment [PDF]

, 2005
The present study examined the way in which the exercise-related motives of external regulation, introjected regulation, and identified regulation interacted with intrinsic motivation to relate to exercise enjoyment.
Karageorghis, CI, Vlachopoulos, SP
core  

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Noninvasive prediction of Blood Lactate through a machine learning-based approach. [PDF]

, 2019
We hypothesized that blood lactate concentration([Lac]blood) is a function of cardiopulmonary variables, exercise intensity and some anthropometric elements during aerobic exercise.
Casaburi, Richard, Chen, Yu-Jen, Fu, Tieh-Cheng, Huang, Shu-Chun, Liao, Ming-Feng, Liu, Kuo-Cheng, Su, Hong-Ren   +6 more
core   +3 more sources

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source