Results 181 to 190 of about 981,197 (361)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

EFFECTS OF EXERCISE THERAPY AIMING AT IMPROVEMENT IN PHYSICAL FITNESS ON DYSPNEA AND HEALTH-RELATED QOL IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

, 2002
Yoichi Nakamura, Kiyoji Tanaka, Ryosuke Shigematsu, Masaki Nakagaichi, Kazuyuki Kamahara, Masakí Inoue   +5 more
openalex   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Effects of Exercise and Testosterone Replacement Therapy on Elderly Males with Osteoarthritis and Hypogonadism

, 2000
Kristen J. Williams, Jaspreet Kaur, W. Edwin Langbein, EG Collins, EB Mak, Edward Hines   +5 more
openalex   +1 more source

Augmented sympathetic vasoconstriction in exercising forearms of postmenopausal women is reversed by oestrogen therapy [PDF]

, 2004
Paul J. Fadel, Zhongyun Wang, Hitoshi Watanabe, Debbie Arbique, Wanpen Vongpatanasin, Gail D. Thomas   +5 more
openalex   +1 more source

Effectiveness of Exercise Therapy for Postpartum Urinary Incontinence-Systematic Review. [PDF]

J Clin Med
Cuesta-Paredes M, Labata-Lezaun N, Orts-Ruiz C, López-de-Celis C, Estébanez-de-Miguel E.   +4 more
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The exercise therapy to diseases of internal medicine

, 1998
Shizuo Sakamoto, Yoshiko Nakajima, KENKI TANAKA, Kunihiko Aizawa, Yôko Tanaka, Toshihiko Iijima   +5 more
openalex   +2 more sources

Examination of the Immediate Effects of SPIDER-Based Exercise Therapy for Patients with Parkinson’s Disease

, 2023
Yuki SOTOME, Ryo Onuma, Yasushi Kurihara, Tadamitsu Matsuda   +3 more
openalex   +2 more sources