Results 91 to 100 of about 347,819 (383)

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Self-Reported Low Vitality, Poor Mental Health, and Low Dietary Restraint Are Associated with Overperception of Physical Exertion

Journal of Obesity, 2010
Objective. We investigated whether perceived exertion, in comparison to the physiological response to exercise, was associated with self-reported vitality, mental health, and physical function during daily activities, or weight control behaviors. Design.
Paula C. Chandler-Laney, David W. Brock, Barbara A. Gower, Jessica A. Alvarez, Nikki C. Bush, Gary R. Hunter   +5 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Dose–response relation between perceived physical exertion during healthcare work and risk of long-term sickness absence

Scandinavian Journal of Work, Environment & Health, 2012
OBJECTIVE: An imbalance between physical work demands and physical capacity of the worker may be a risk factor for poor health. Perceived physical exertion provides information about the individual perception of the work demands relative to the capacity ...
Lars L Andersen, Thomas Clausen, Roger Persson, Andreas Holtermann   +3 more
doaj   +1 more source

DISTINGUISHING THE SOURCE OF MARKET POWER: AN APPLICATION TO CIGARETTE MANUFACTURING [PDF]

We compare nonparametric and nonstructural market power tests using data from the cigarette manufacturing industry. Tests are implemented to examine both monopoly and monopsony power exertion by cigarette manufacturers. Results indicate that market power
Love, H. Alan, Raper, Kellie Curry, Shumway, C. Richard   +2 more
core   +1 more source

Tracking daily fatigue fluctuations in multiple sclerosis : ecological momentary assessment provides unique insights [PDF]

, 2017
The preparation of this manuscript was supported by a UK Economic and Social Research Council (ESRC) PhD studentship (ES/1026266/1) awarded to DP. The study was funded by the Psychology Unit at the University of Southampton. The authors declare that they
Liossi, Christina, Moss-Morris, Rona, Powell, Daniel J. H., Schlotz, Wolff   +3 more
core   +3 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Energy and thermodynamical study of a small innovative compressed air energy storage system (micro-CAES) [PDF]

, 2015
There is a growing interest in the electrical energy storage system, due to the high penetration of the energy produced by renewable sources, the possibility of leveling the absorption peak of the electric network (peak shaving) and the advantage of ...
Cedola, Luca, De Lieto Vollaro, Roberto, Faga, Francesco, Tallini, Alessandro, Vallati, Andrea   +4 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Triggering of acute myocardial infarction by heavy physical exertion. Protection against triggering by regular exertion. Determinants of Myocardial Infarction Onset Study Investigators.

New England Journal of Medicine, 1993
BACKGROUND Despite anecdotal evidence suggesting that heavy physical exertion can trigger the onset of acute myocardial infarction, there have been no controlled studies of the risk of myocardial infarction during and after heavy exertion, the length of ...
M. Mittleman, M. Maclure, G. Tofler, J. Sherwood, R. Goldberg, J. Muller   +5 more
semanticscholar   +1 more source