Results 221 to 230 of about 357,527 (386)

NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2

FEBS Open Bio, EarlyView.
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper, Sridhar Sreeramulu, Benjamin T. Lanham, Elizabeth M. Engle, David Fushman, Harald Schwalbe   +5 more
wiley   +1 more source

Strength and Perceived Effort in Repetitive Upper-Limb Tasks: An OCRA Method Analysis of 900 Workers. [PDF]

Med Lav
Gobbo S, Bullo V, Favro F, Pavan D, Doro B, Bortoletto A, De Palma G, Sala E, Mattioli S, Di Blasio A, Bergamin M.   +10 more
europepmc   +1 more source

Devices of Engagement: On Borgmann's Philosophy of Information and Technology [PDF]

, 2002
Verbeek, Peter-Paul
core   +2 more sources

RELATIONSHIP OF PERCEIVED EXERTION AND HEART RATE DURING EXERCISE TESTING AND TRAINING IN CARDIAC PATIENTS

, 1985
Thomas J. Birk, Karin A. Jeffery, C. Birk, L. Theurer, G. W. Johnson   +4 more
openalex   +1 more source

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

FEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno, Aki Terasaki, Yuiko Imai, Yuri Kimura, Yuna Kojima, Misa Irie, Koya Odaira, Mina Noura, Shuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +12 more
wiley   +1 more source

Changes in saddle setback and intensity affect comfort and lower limb kinematics in recreational cyclists. [PDF]

Sci Rep
Encarnación-Martínez A, Rizo-Albero J, Pérez-Soriano P.   +2 more
europepmc   +1 more source

PERCEIVED EXERTION AND SELECTED PHYSIOLOGICAL RESPONSES DURING BICYCLE EXERCISE UNDER HYPEROXIC CONDITIONS

, 1982
Patricia M. Mihevic, William C. Byrnes, Steven M. Horvath   +2 more
openalex   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Rating of perceived exertion in continuous sports: a scoping review with evidence gap map. [PDF]

Front Sports Act Living
Torres G, Maia F, Nakamura FY, Neiva HP, Sousa A.   +4 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source