Results 41 to 50 of about 93,515 (146)

Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.

PLoS Genetics, 2012
Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide. Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk alleles for glaucoma-related optic nerve disease.
Janey L Wiggs, Brian L Yaspan, Michael A Hauser, Jae H Kang, R Rand Allingham, Lana M Olson, Wael Abdrabou, Bao J Fan, Dan Y Wang, Wendy Brodeur, Donald L Budenz, Joseph Caprioli, Andrew Crenshaw, Kristy Crooks, Elizabeth Delbono, Kimberly F Doheny, David S Friedman, Douglas Gaasterland, Terry Gaasterland, Cathy Laurie, Richard K Lee, Paul R Lichter, Stephanie Loomis, Yutao Liu, Felipe A Medeiros, Cathy McCarty, Daniel Mirel, Sayoko E Moroi, David C Musch, Anthony Realini, Frank W Rozsa, Joel S Schuman, Kathleen Scott, Kuldev Singh, Joshua D Stein, Edward H Trager, Paul Vanveldhuisen, Douglas Vollrath, Gadi Wollstein, Sachiko Yoneyama, Kang Zhang, Robert N Weinreb, Jason Ernst, Manolis Kellis, Tomohiro Masuda, Don Zack, Julia E Richards, Margaret Pericak-Vance, Louis R Pasquale, Jonathan L Haines   +49 more
doaj   +1 more source

Early oxidation‐related changes in aqueous humor following eye exposure to ultraviolet‐A radiation

Photochemistry and Photobiology, EarlyView.
UVA exposure induces early oxidative alterations in the aqueous humor, disrupting its antioxidant balance. Levels of ascorbic acid, reduced glutathione (GSH), and the GSH/GSSG ratio decrease, while oxidized glutathione (GSSG), S‐glutathionylated proteins (PSSG), and malondialdehyde (MDA), a lipid peroxidation by‐product, increase.
Corinne Zinflou, Patrick J. Rochette
wiley   +1 more source

Is it worthwhile to conduct a randomized controlled trial of glaucoma screening in the United Kingdom? [PDF]

, 2013
ObjectivesTo assess the value of conducting a glaucoma screening randomized controlled trial in the UK.MethodsDecision model based economic evaluation and value of information analysis. Model derived from a previous health technology assessment.
Campbell, M, Azuara-Blanco, Augusto; id_orcid, Prior, M. E., Campbell, S. E., Francis, Jill, Prior, M, Campbell, S, Hernández, Rodolfo, Vale, Luke, Ramsay, C, Campbell, Susan, Ramsay, Craig, Burr, Jennifer, Azuara-Blanco, A., Ramsay, C. R., Hernández, R, Francis, J., Vale, L, Hernandez, R. A., Burr, J. M., Campbell, M. K., Azuara-Blanco, A, Campbell, Marion, Azuara-Blanco, Augusto, Francis, J, Prior, Maria, Burr, J, Vale, L. D.   +27 more
core   +1 more source

Correlations between amyloid-β peptide levels in aqueous humor and retinal thickness in patients with glaucoma

Scientific Reports
Amyloid-β (Aβ) accumulation is a well-established cause of neurotoxicity in the brain and a major factor in Alzheimer’s disease. However, its role in ocular neurodegeneration remains unclear.
Tsutomu Ohashi, Takayuki Harada, Kazuhiko Namekata, Yasuhiro Shinmei, Akio Fujiya, Maiko Yoshida, Takashi Kojima   +6 more
doaj   +1 more source

Applications of Mesenchymal Stromal Cells for Treatment of Diseases

MedComm, Volume 7, Issue 9, September 2026.
This schematic summarizes the major therapeutic mechanisms of MSCs across different disease systems and highlights factors associated with MSCs dysfunction, together with current strategies to enhance MSCs function and therapeutic efficacy. This summary diagram illustrates that MSCs exert therapeutic effects in various diseases through multiple ...
Dongmei Xue, Yongsheng Li, Lei Wu
wiley   +1 more source

Retinal oxygen saturation and retinal vessel diameter in glaucoma patients before and after trabeculectomy

Acta Ophthalmologica, Volume 104, Issue 5, Page 544-550, August 2026.
Abstract Purpose To compare retinal vessel oxygen saturations and diameters before, 1 and 3 months after trabeculectomy. Methods Retinal oxygen saturations and vessel diameters were obtained using retinal oximetry. The effect of the postoperative intraocular pressure (IOP) decrease on the arteriovenous difference (AV‐difference) was evaluated ...
S. Kemp, A. Ahmadzadeh, B. Schmidt, O. N. Klefter, L. Kessel, D. Bach‐Holm   +5 more
wiley   +1 more source

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

MedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao   +12 more
wiley   +1 more source

Central retinal artery occlusion and non-arteritic anterior ischemic optic neuropathy associated with an overlap syndrome: a case report

Journal of Medical Case Reports, 2008
Introduction An "overlap syndrome" is defined as the sequential appearance over time of two or more risk factors for glaucomatous damage. The appearance of a new risk factor can alter the course and prognosis of previously stable disease.
Lima Verônica C, Prata Tiago S, Liebmann Jeffrey M, Ritch Robert   +3 more
doaj   +1 more source

Anterior chamber flare and central macular thickness after trabeculectomy versus after phacoemulsification

Acta Ophthalmologica, Volume 104, Issue 4, Page 402-409, June 2026.
Abstract Purpose To compare the inflammatory response in the eye after trabeculectomy to after phacoemulsification, focusing on anterior chamber flare (AC flare) and central macular thickness (CMT). Methods Data from 436 participants in two randomized controlled trials were analysed.
Yasmeen Ahmed, Jesper Høiberg Erichsen, Afrouz Ahmadzadeh, Lars Morten Holm, Line Kessel, Daniella Bach‐Holm   +5 more
wiley   +1 more source

The Frequency of Exfoliation Syndrome in the Central Anatolia Region of Turkey

Journal of Ophthalmology, 2014
Aim. The aim of this study was to investigate the frequency of exfoliation syndrome in the Central Anatolia region of Turkey and to evaluate its relationship with cardiovascular and ocular diseases. Methods.
Raşit Kılıç, Hafize Sezer, Sebile Ü. Çomçalı, Serdar Bayraktar, Gökay Göktolga, Yasin Çakmak, Abdi B. Çetin, Tongabay Cumurcu   +7 more
doaj   +1 more source