Results 71 to 80 of about 5,440,860 (285)
British Journal of Clinical Pharmacology, EarlyView.Aim Londamocitinib (AZD4604) is an inhaled, selective Janus kinase 1 (JAK1) inhibitor in development for asthma. This open‐label, two‐part, phase I clinical study (NCT06157255) used a radiolabelled microtracer approach to evaluate the absolute bioavailability and the absorption, distribution, metabolism and excretion (ADME) of inhaled londamocitinib ...
Camille Riff +12 more
wiley +1 more source
Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial
British Journal of Clinical Pharmacology, EarlyView.Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich +24 more
wiley +1 more source
QUANTIFICATION OF BACK DIFFUSION IN RADON AND THORON EXHALATION RATE MEASUREMENTS
Radiation Protection Dosimetry, 2020 Abstract The radon (222Rn) and thoron (220Rn) fluxes from the soil and building materials are the major contributors to their indoor levels. Hence, the measurement of radon and thoron exhalation rates from the source matrix becomes the foremost step in controlling the indoor radon and thoron exposure.
N, Chitra +5 more
openaire +2 more sources
BMEMat, EarlyView.This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao +3 more
wiley +1 more source
In this study, we investigate the relationship between breathing patterns and cardiac autonomic nervous activity during spontaneous breathing. Electrocardiograms and respiratory signals were simultaneously monitored in six subjects for 5 min while in a ...
Yutaka Yoshida, Emi Yuda
core +1 more source
Journal of Radiation Research and Applied Sciences, 2016 The presence of natural radioactivity and radon exhalation from building materials contribute to the radiation dose received by human. So, it is essential to evaluate the activity levels of the primordial radionuclides (238U, 226Ra, 232Th and 40K ...
Nisha Sharma +3 more
doaj +1 more source
On the exhalation rate of radon by man [PDF]
, 1990 This paper describes some aspects of the exhalation rate of radon by man which may be relevant to its internal dosimetry and, therefore, to possible radiobiological consequences.
Rundo, J., Markun, F., Plondke, N.J.
core
Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality
BMEMat, EarlyView.Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim +9 more
wiley +1 more source
Influence of thoron on measurement results of radon exhalation rate
, 2002 Because of thoron exhalation, the measurement results of radon exhalation rate using a local still method is usually larger than the true value of radon flux rate of the monitored material surface.
Ling, Q, Leung, Zhao, GZ, Xiao, DT
core
Chemistry – A European Journal, EarlyView.Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi +6 more
wiley +1 more source