Results 91 to 100 of about 9,097,159 (286)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The effect of piston bowl temperature on diesel exhaust emissions [PDF]

, 2005
In modern, high-speed, direct injection diesel engines for passenger vehicles, there is extensive impingement of the fuel sprays on to the piston bowl walls.
Ladommatos, N, Zhao, H, Xiao, Z
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Integrating heat recovery from milk powder spray dryer exhausts in the dairy industry [PDF]

, 2011
Heat recovery from milk powder spray dryer exhausts has proven challenging due to both economic and thermodynamic constraints. Integrating the dryer with the rest of the process (e.g.
Walmsley, Michael R.W., Michael R.W. Walmsley, Martin J. Atkins, Atkins, Martin John, James R. Neale, Neale, James R.   +5 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Greenhouse Gas Payback Time of Different HVAC Systems in the Renovation of Nordic District-Heated Multifamily Buildings Considering Future Energy Production Scenarios

Buildings
The European Union (EU) has implemented several policies to enhance energy efficiency. Among these policies is the objective of achieving energy-efficient renovations in at least 3% of EU buildings annually.
Alaa Khadra, Jan Akander, Jonn Are Myhren   +2 more
doaj   +1 more source

Numerical and physical modeling of heat transfer in the exhaust system of a piston engine in stationary conditions

EPJ Web of Conferences, 2019
Thermomechanical perfection of exhaust systems largely determines the efficiency of the engine boost system. The article presents the results of numerical simulation and experimental study of heat transfer of gas flows in profiled exhaust systems of ICE.
Plotnikov Leonid, Nevolin Alexandr, Misnik Mariya   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

ANALYSIS OF THE POSSIBILITY OF USING EXHAUST GAS COMPOSITION IN THE DIAGNOSIS OF A DIESEL ENGINE

Scientific Journal of Gdynia Maritime University
The article analyzes the impact of malfunctions in compression-ignition engine systems on exhaust composition and cycle parameters. A naturally aspirated, single-cylinder, four-stroke Farymann Diesel D10 engine was studied, with simulated common ...
Patrycja Puzdrowska, Wiktoria Nowicka
doaj   +1 more source