Results 181 to 190 of about 863,856 (339)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Art-induced psychological well-being: Individual traits shape the beneficial effects of aesthetic experiences. [PDF]

PLoS One
Castellotti S, Gragnoli E, Baglioni G, Criminisi R, Giangrasso B, Del Viva MM.   +5 more
europepmc   +1 more source

Research on the Application of Intelligent Virtual Reality Technology in Museum Exhibitions and Evaluation of the Experience [PDF]

Haijie Li, Luo Song
openalex   +1 more source

Exhibition road

British Dental Journal, 2023
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

"Eugenics is an integral aspect of our global scientific and political culture:" interview with Marius Turda. [PDF]

Hist Cienc Saude Manguinhos
Turda M, Mannheimer V.
europepmc   +1 more source

A Study on the Exhibitional Utilization of Pneumatic Structure

, 2020
Hyosun Bang, Ikseo Choi
openalex   +2 more sources

Analysing Narration of Museum Exhibition Information for Young Visitors

, 2023
Yang Jingfei, Rahinah Ibrahim
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Looking at people looking at art: observations of art interactions in an everyday urban environment. [PDF]

Front Psychol
Knoll AL, Mikuni J, Specker E.
europepmc   +1 more source