Results 41 to 50 of about 203,466 (305)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Safe luminous spaces configuration in exhibit rooms

, 2022
La iluminación natural aporta importantes beneficios en los espacios arquitectónicos, otorgando dinamismo y enriqueciendo la experiencia de los ocupantes en los aspectos de salud y comodidad lumínica y visual, mientras promueve la sustentabilidad energética.
Aravena Riffo, Javiera Ignacia, Roldán Rojas, Jeannette Auristela   +1 more
openaire   +1 more source

For scientists, for students or for the public? : the shifting roles of natural history museums [PDF]

, 2010
This article aims to discuss the main roles of natural history museums and to show how these purposes have evolved and adapted throughout the museums’ history, as a response to the development of natural sciences and societal change, from their creation ...
Delicado, Ana
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

APLIKASI ALUR CERITA (STORYLINE) PADA TATA PAMERAN DI UPTD MUSEUM KABUPATEN SUBANG

Patanjala: Jurnal Penelitian Sejarah dan Budaya, 2013
Abstrak Artikel ini berjudul “Aplikasi Alur Cerita (Storyline) Tata Pameran di UPTD Museum Kabupaten Subang”. Permasalahan yang diteliti adalah tentang bagaimana kondisi faktual tata pameran di UPTD Museum Daerah Kabupaten Subang?
Yusep Wahyudin
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Electric Shadows (Dianying) * [PDF]

, 2010
Catalogue Essay on Isaac Julien's installation "Ten Thousand Waves".
Nash, Mark
core  

Museums of Landscape. A Project for the Tuscia’s Archaeological Heritage [PDF]

Athens Journal of Architecture
In recent decades, numerous initiatives have seen the aims of Italian architects and archaeologists converge on the necessity to found the country’s future on the basis of a renewal of cultural heritage that represents it.
Francesca Coppolino, Bruna Di Palma
doaj   +1 more source