Results 171 to 180 of about 8,161,835 (383)
It seems obvious that I could have failed to exist. My parents could easily never have met, in which case I should never have been conceived and born. The like applies to everyone. More generally, it seems plausible that whatever exists in space and time could have failed to exist. Events could have taken an utterly different course.
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The Existence of Homogeneous Groups of Large Ions [PDF]
Oswald Blackwood
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B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez+17 more
wiley +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Giving back life to abandoned traditional montenegrian houses. Saving cultural heritage from vanishing by giving them purpose and making them attractive for the coming generations. The purpose is going to be based on local food production and local arts and crafts.
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IV.—Viscosity and association. Part III. The existence of racemic compounds in the liquid state [PDF]
Ferdinand Bernard Thole
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