Results 201 to 210 of about 2,776,395 (308)

The Existence and Uniqueness of Solutions in the Leaf Photosynthesis-Transpiration-Stomatal Conductance Model for C3 Plants. [PDF]

Glob Chang Biol
Masutomi Y, Kobayashi K.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Mathematical Model Analysis for the Transmission Dynamics of Wheat Yellow Rust Disease: In Case of Melga Woreda, Sidama Regional State, Ethiopia. [PDF]

Sci Rep
Fantaye AK, Dawed MY, Birhanu ZK.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Convergence Analysis of Controlled Particle Systems Arising in Deep Learning: From Finite to Infinite Sample Size. [PDF]

Appl Math Optim
Liao H, Mészáros AR, Mou C, Zhou C.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Evolution of health system resources and factors associated with the quality of care for epidemic-prone diseases in Guinea: a national cross-sectional study. [PDF]

Front Epidemiol
Kpamy DO, Cherif F, Conde S, Traore FA, Sidibe S, Diarra B, Winch PJ, Toure A, Keita S, Doumbia S, Delamou A.   +10 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Flow of Dilute Aqueous Polymer Solutions in a Heterogeneous Porous Medium: Existence Results for Steady and Unsteady Cases. [PDF]

Polymers (Basel)
Baranovskii ES, Artemov MA.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source