Results 261 to 270 of about 8,161,835 (383)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Healthcare Models and Quality Indicators in the Management of Patients with Heart Failure in Spain: Results from the CARABELA-HF Initiative. [PDF]

J Clin Med
Mediavilla I, Anguita M, González Franco Á, Leal M, Carabela-Hf Scientific Committee, Soto JF.   +5 more
europepmc   +1 more source

XXXIX.—On doubts respecting the Existence of Bird-catching Spiders [PDF]

W Macleay
openalex   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

God and the Possibility of a Moral Right to Privacy. [PDF]

Sophia
Lundgren B.
europepmc   +1 more source

Evidence Presented for the Existence of the Micturition Center in the Medulla

, 1959
Masaru Kuru, Hideo Ozaki
openalex   +2 more sources

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Evaluating the efficiency of emergency operation centers during pandemics: a cross-sectional study with operational managers in Iran. [PDF]

Front Public Health
Sartipi M, Aminafshar A, Pakzad A, Shafiei M, Farahmandnia H, Tavan A.   +5 more
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Periodontitis Frequently Exists in Patients with Colorectal Carcinoma and Causes Supplementary Impairment of Insulin Resistance. [PDF]

Metabolites
Zivkovic M, Boban M, Vrazic D, Vulic I, Budimir I, Blazevic N, Vcev A, Nikolic M.   +7 more
europepmc   +1 more source