Results 261 to 270 of about 6,731,721 (317)

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Fear effect on the mobility of individuals in a spatially heterogeneous environment: a delayed diffusive SPIR epidemic model. [PDF]

Sci Rep
Sarmad G, Djilali S, Bentout S, Tridane A.   +3 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Changes in Family Spirituality in Response to Family Intervention Utilizing the Family Life Review. [PDF]

Nurs Rep
Hohashi N, Yano H.
europepmc   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Analysis of fractional-order model for the transmission dynamics of malaria via Caputo-Fabrizio and Atangana-Baleanu operators. [PDF]

Sci Rep
Agbata BC, Dervishi R, Gümüş M, Smerat A, Mbah GCE.   +4 more
europepmc   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

Deep-sea mining: Superficial riches, deep hidden costs

Sumaila UR, Alam L, Pradhoshini K, Flint R, Singh P, Billon PL, Mosnier F, Amon D, Abdallah P, Aheto D, Alger J, Anna Z, Barnes C, Fritsch D, Giron A, Gjerde K, Hilmi N, Karuaihe S, Levin L, Mohammed, Sukhdev P, Tudhope A, Thiele T, Villasante S, Wilson M.   +24 more
europepmc   +1 more source

Delving into the Correlation between Magnetic and Lattice Degrees of Freedom from Magnetocaloric and Magnetovolume Effects in Lu₂Fe₁₇ Ribbons. [PDF]

J Phys Chem C Nanomater Interfaces
Garrido Álvarez JL, Arreguín-Hernández ML, Echevarría-Bonet C, Gorria P, Puente-Orench I, Fauth F, Blanco JA, Sánchez Llamazares JL, Álvarez-Alonso P.   +8 more
europepmc   +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source