Results 91 to 100 of about 4,557,251 (286)

Existence of solutions to singular fourth-order elliptic equations

Electronic Journal of Differential Equations, 2013
Using a method developed by Ambrosetti et al [1,2] we prove the existence of weak non trivial solutions to fourth-order elliptic equations with singularities and with critical Sobolev ...
Mohammed Benalili, Kamel Tahri
doaj  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Existence of Nonoscillatory Solutions of First-Order Neutral Differential Equations

Abstract and Applied Analysis, 2011
This paper contains some sufficient conditions for the existence of positive solutions which are bounded below and above by positive functions for the first-order nonlinear neutral differential equations. These equations can also support the existence of
Božena Dorociaková, Anna Najmanová, Rudolf Olach   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Existence and Uniqueness of Second-Order Impulsive Delay Differential Systems

Axioms
In this paper, we study the existence and uniqueness of second-order impulsive delay differential systems. Firstly, we define cosine-type and sine-type delay matrix functions, which are used to derive the solutions of the impulsive delay differential ...
Yingxia Zhou, Mengmeng Li
doaj   +1 more source

Existence Results for a Fully Fourth-Order Boundary Value Problem

Journal of Function Spaces and Applications, 2013
We discuss the existence of solution for the fully fourth-order boundary value problem u(4)=f(t,u,u′,u′′,u′′′), 0≤t≤1, u(0)=u(1)=u′′(0)=u′′(1)=0. A growth condition on f guaranteeing the existence of solution is presented.
Yongxiang Li, Qiuyan Liang
doaj   +1 more source