Results 131 to 140 of about 4,557,251 (286)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

COVID-19 (SARS-COV-2): Transformations in medicine, our existence, and world order?

Journal of Family Medicine and Primary Care, 2020
Jayanta Bhattacharya
doaj   +1 more source

Existence of periodic solutions for higher-order nonlinear difference equations

Electronic Journal of Differential Equations, 2016
In this article, we study a higher-order nonlinear difference equation. By using critical point theory, we establish sufficient conditions for the existence of periodic solutions.
Jianhua Leng
doaj  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Existence of solutions for second-order impulsive boundary-value problems

Electronic Journal of Differential Equations, 2012
In this article we discuss the existence of solutions of second-order boundary-value problems subjected to impulsive effects. Our approach is based on fixed point theorems.
Abdelkader Boucherif, Ali S. Al-Qahtani, Bilal Chanane   +2 more
doaj  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Existence of solutions for a fourth-order boundary-value problem

Electronic Journal of Differential Equations, 2008
In this paper, we use the lower and upper solution method to obtain an existence theorem for the fourth-order boundary-value problem $$displaylines{ u^{(4)}(t)=f(t,u(t),u'(t),u''(t),u'''(t)),quad ...
Yang Liu
doaj  

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Existence of solutions for fourth-order PDEs with variable exponents

Electronic Journal of Differential Equations, 2009
In this article, we study the following problem with Navier boundary conditions $$displaylines{ Delta _{p(x)}^2u=lambda | u| ^{p(x)-2}u+f(x,u)quad hbox{in }Omega , cr u=Delta u=0quad hbox{on }partial Omega .
Mimoun Moussaoui, Fouzia Moradi, Abdelrachid El Amrouss   +2 more
doaj