Results 121 to 130 of about 8,272,044 (305)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
On the existence of pure strategy equilibria in large generalized games with atomic players [PDF]
We consider a game with a continuum of players where only a finite number of them are atomic. Objective functions and admissible strategies may depend on the actions chosen by atomic players and on aggregate information about the actions chosen by non ...
Riascos Villegas, Alvaro +1 more
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Non-existence result for quasi-linear elliptic equations with supercritical growth [PDF]
, 2007 summary:We obtain a non-existence result for a class of quasi-linear eigenvalue problems when a parameter is small. By using Pohozaev identity and some comparison arguments, non-existence theorems are established for quasi-linear eigenvalue problems ...
Yang, Zuodong, Yuan, Junli
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An existence result for a Neumann problem
, 2015 The main result of this paper deals with the existence of at least one positive solution for a second order Neumann boundary value problem. Such a result is obtained by using an abstract coincidence point theorem that allows to get our conclusion under ...
Livrea, Roberto, Candito, Pasquale
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Existence result of continuous positive solutions for a reaction–diffusion system
Partial Differential Equations in Applied MathematicsThis paper mainly seeks to contribute to the study of a quasilinear parabolic reaction–diffusion system of arbitrary order with initial conditions. Using potential analysis techniques, we establish the existence of continuous positive solutions.
Mounir Redjouh +2 more
doaj +1 more source
Existence Results for Nonlinear Integral Equations
Journal of Mathematical Analysis and Applications, 1995 The author gives sufficient conditions for the existence of a solution of the nonlinear Volterra integral equation \[ y(t)= h(t)+ \int^t_0 k(t, s) f(s, y(s)) ds, \qquad 0\leq ...
openaire +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source