Results 81 to 90 of about 8,335 (252)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Editorial: A new science of suffering, the wisdom of the soul, and the new behavioral economics of happiness: towards a general theory of well-being

Frontiers in Psychology, 2023
Paul T. P. Wong, Lok Sang Ho, Claude-Hélène Mayer, Fan Yang, Richard G. Cowden   +4 more
doaj   +1 more source

Growing empathy through art therapy, life story, and relationships: experiential learning in adult day services

Frontiers in Psychology
IntroductionEmpathy is a fundamental element of high-quality healthcare, though it has been shown to be in decline among medical students and residents. Appeals have therefore been made for the development of evidence-based empathy-enhancing experiential
L. Blake Peeples, L. Blake Peeples, L. Blake Peeples, Benjamin C. Thompson, Benjamin C. Thompson, Jackie B. Tucker, Jackie B. Tucker, LaDerrick Smith, Amy Brown, Keisha D. Carden, Keisha D. Carden, Keisha D. Carden, Anne Halli-Tierney, Angel C. Duncan, Neelum T. Aggarwal, Jessica Y. Allen, Rebecca S. Allen, Rebecca S. Allen, Rebecca S. Allen, Daniel C. Potts, Daniel C. Potts, Daniel C. Potts   +21 more
doaj   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source

Examining hedonic and eudaimonic well-being in emerging adults from Hong Kong: Does amor Fati account for well-being beyond the role of affectivity?

Acta Psychologica
This study examines the significance and utility of amor fati—an existential construct reflecting complete life affirmation—as a positive psychological variable in predicting both hedonic and eudaimonic well-being among emerging adults in Hong Kong ...
Stephen Cheong Yu Chan, Qi Lu Huang, Edward C. Chang   +2 more
doaj   +1 more source

Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education

Advanced Science, EarlyView.
We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua, Anira Escrichs, Yonatan Sanz Perl, Morten L. Kringelbach, Adele Diamond, Solange Denervaud, Gustavo Deco   +6 more
wiley   +1 more source

Investigating the association of reading habits and attitudes with meaningful living: The mediating role of subjective well-being

Acta Psychologica
This study explores the impact of reading habits on Turkish language teachers' perception of a meaningful life, with a particular focus on the mediating role of subjective well-being.
Uğur Özbilen, Ahmet Zeki Güven, Tuğrul Gökmen Şahin, Emrullah Banaz   +3 more
doaj   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Understanding psychological flourishing across the lifespan: an integrative review of theory and evidence

Frontiers in Psychology
Psychological flourishing is increasingly recognised as a multidimensional construct within contemporary positive psychology. It extends beyond the mere absence of psychopathology to encompass the active presence of positive functioning across emotional,
Wang Meiping, Shamim Akhter, Mengqiu Tan
doaj   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source