Results 141 to 150 of about 18,685,718 (259)

Editorial: A new science of suffering, the wisdom of the soul, and the new behavioral economics of happiness: towards a general theory of well-being

Frontiers in Psychology, 2023
Paul T. P. Wong, Lok Sang Ho, Claude-Hélène Mayer, Fan Yang, Richard G. Cowden   +4 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Development and Validation of a Self-Report Measure of Existential Well-Being. [PDF]

Clin Pract Epidemiol Ment Health
Picardi A, Filastro A.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Existential Boredom Re-examined

, 2019
This paper takes issue with interpretations of boredom as an existential mood that must be avoided. Through addressing some of the inconsistencies in Heidegger’s account of boredom, and relatedly exploring its intricate relationship with nothingness ...
Gilliam, Christian
core  

Existential Well-Being in Nature: A Cross-Cultural and Descriptive Phenomenological Approach. [PDF]

J Med Humanit
Baklien B, Marthoenis M, Thurston M.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Subjective Measures of Well-being [PDF]

well-being, objective, subjective, measurement, quality of life, worth, happiness adjusted life ...
Veenhoven, Ruut
core  

Relationship Between Resilience, Social Support, Existential Well-Being and Negative Emotions in Cervical Cancer Patients: a Mediation Analysis. [PDF]

J Cancer
Ma Y, Chen S, Dong H, Guo R, Liu R, Xie J, Sun Z.   +6 more
europepmc   +1 more source