Results 111 to 120 of about 68,214 (292)

Assessing the impact of coordinated COVID-19 exit strategies across Europe [PDF]

open access: yesScience, 2020
Ruktanonchai N   +14 more
europepmc   +2 more sources

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

open access: yesMolecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza   +3 more
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

open access: yesMolecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh   +5 more
wiley   +1 more source

Making Sense of Health-Related Labor-Market Exits and Disability: Evidence from the American Voices Project

open access: yesRSF: The Russell Sage Foundation Journal of the Social Sciences
Issues around stigma and deservingness may be particularly salient for people who stop working due to health-related reasons. Although historically those experiencing disability have been viewed as “deserving” of assistance, disability has also been ...
James Hiebert   +2 more
doaj   +1 more source

Disengagement from Ideologically-Based and Violent Organizations: A Systematic Review of the Literature

open access: yesJournal for Deradicalization, 2016
Research on disengagement from violent extremism is an emerging field of inquiry. As compared to the related field of radicalization, there have been fewer studies of disengagement.
Steven Windisch   +3 more
doaj  

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

open access: yesMolecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza   +5 more
wiley   +1 more source

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