Results 111 to 120 of about 28,286 (251)

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

Insights into the molecular mechanism of Sjogren's syndrome [PDF]

, 2017
Sjogren’s syndrome (SS) is a chronic autoimmune disease, that affects primarily salivary and lacrimal glands, leading to increased morbidity. Recent studies indicate that loss of salivary gland function is associated with defective cell polarity ...
Langara, Hans A.
core  

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Evolving treatments for Sjögren disease: current approaches and emerging targets

Internal Medicine Journal, EarlyView.
Abstract Sjögren disease (SjD) is a prevalent systemic autoimmune condition characterised by exocrine gland dysfunction, systemic inflammation and heterogeneous organ involvement. Current management remains largely symptomatic, with no approved disease‐modifying therapies available and substantial unmet clinical need. However, advances in understanding
Mansi Bhurani, Adrian Y. S. Lee, Maureen Rischmueller, Alberta Hoi   +3 more
wiley   +1 more source

Piscirickettsiosis in Farmed Turbot, Scophthalmus maximus

Journal of Fish Diseases, EarlyView.
ABSTRACT Piscirickettsia salmonis is a well‐established intracellular pathogen of farmed Atlantic salmon around the world. The bacterium has also been detected from a number of other hosts including lumpfish (Cyclopterus lumpus), seabass (Dicentrarchus labrax) and rainbow trout (Oncorhynchus mykiss).
Hanne K. Nilsen, Magne Kjerulf Hansen, Raoul Kuiper, Jan Inge Øvrebø, Kjersti Sturød, Maryam Saghafian, Snorre Gulla, Anne Berit Olsen, Duncan J. Colquhoun, Ole Bendik Dale   +9 more
wiley   +1 more source

Alternative Protein Sources in Poultry and Pig Nutrition—A Review

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Proteins are an essential nutrient for the viability of all animals, enabling organisms to grow, regenerate and defend themselves against pathogenic organisms. Soybean and soybean‐based materials are commonly used to supplement protein in animal nutrition.
Lukáš Čumplík, Dana Zálešáková, Jakub Novotný, Lenka Kudlová, Leoš Pavlata, Ondřej Šťastník   +5 more
wiley   +1 more source

Pancreas, Muscle, and Subcutaneous Fat Atrophy in Patients Undergoing Radiation for Neuroblastoma

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Background/Objectives Radiation therapy (RT) is part of standard‐of‐care therapy in high‐risk neuroblastoma (HR‐NBL) but can significantly affect nearby tissue. The objectives of this study were (1) to characterize changes in pancreas volume after RT and (2) to characterize changes in body composition, including body weight percentile ...
Pradipta Debnath, Marissa Ray, Luke Pater, Alexandra O. Glenn, Stephen Hartman, Elanchezhian Somasundaram, Todd Jenkins, Juan P. Gurria, Katherine Somers, Andrew T. Trout, Meera Kotagal   +10 more
wiley   +1 more source

SJOGREN’S SYNDROME

Journal of the Dow University of Health Sciences, 2007
Sjogren's syndrome is an autoimmune and a chronic inflammatory disorder characterized by the infiltrationo f the exocrine glands particularly the lacrimal and the salivary glands by the lymphocytes and the plasmacells resulting in xerostomia and ...
Pyar AJi Fazel, Karim Ullah Makki, Husain Haroon, Saira Sheikh   +3 more
doaj  

Ophiopogonin D Mediates Therapeutic Effects on Primary Sjögren's Syndrome by Modulating Gut Microbiota and Metabolite Profiles

Biomedical Chromatography, Volume 40, Issue 6, June 2026.
ABSTRACT This study aimed to investigate the mechanism of ophiopogonin D (OD) in treating primary Sjögren's syndrome (pSS) through integrated analysis of gut microbiota and metabolomics. Non‐obese diabetic/LtJ mice, a well‐established pSS model, were used as the model group and treated with OD or hydroxychloroquine.
Fengtao Pang, Xueyan Shan, Yi Kong, Xiaopo Tang   +3 more
wiley   +1 more source