Results 71 to 80 of about 25,282 (251)

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Construction of Sabatier Volcanoes for CO2 Hydrogenation to C1‐2 Oxygenates Using Data‐Efficient Machine Learning

Advanced Science, EarlyView.
A new data‐efficient framework combining DFT calculations, a neural network model, and automated graph analysis of catalytic reaction networks is proposed and applied to CO2 hydrogenation on transition metal nanoparticles. The analysis shows how efficient C2 oxygenate production requires a balance between CHx formation, C–C coupling, protonation, and ...
Mikhail V. Polynski, Sergey M. Kozlov
wiley   +1 more source

Adaptive Coordination Engineering for Efficient and Robust H2 Release

Advanced Science, EarlyView.
β‐H elimination is a pivotal but challenging step in homogeneous formic acid dehydrogenation reactions due to strict hydride‐metal matching. By using a rationally designed Pd1Ag2 bimetallic system with adaptive Pd1‐Ag2/L2 coordination and formate bridges, it enables boosted formic acid dehydrogenation under ambient air (7.7 times higher than a Pd ...
Xiaolin Jiang, Xiaoyang Yan, Shenglong Jiang, Hongdan Zhu, Heng Wang, Xiaopeng Li, Xiaochun Zhou, Mingdong Zhou, Qian Peng   +8 more
wiley   +1 more source

Bridged h‐BN Nanosheets Coatings: Simultaneous Shielding Atomic‐Oxygen Irradiation and Achieving Superior Friction Performance

Advanced Science, EarlyView.
ABSTRACT To confront extreme space environments, a combination of inorganic and organic coatings can provide a pathway for offering highly durable radiation resistance and anti‐friction simultaneously. Herein, a strong interfacial 3D hydrogen‐bonding network is designed to create robust hexagonal boron nitride (h‐BN) based polymer coatings with ...
Zhuoyi Li, Changning Bai, Xingkai Zhang, Yusheng Liang, Wei Wu, Dingrui Zhou, Tao Du, Chunjin Wang   +7 more
wiley   +1 more source

Solar‐Driven Bifunctional Adsorption‐Storage Films for Ultra‐Fast Dehumidification and Freshwater Supply in Low‐carbon Buildings

Advanced Science, EarlyView.
Bifunctional adsorption‐storage films enable autonomous indoor humidity regulation and freshwater harvesting, rapidly decreasing relative humidity from 90.7% to 21.6% within one hour while producing 1.1 kg·m−2·day−1 of water, offering a passive route towards energy‐efficient humidity control and sustainable indoor environments. ABSTRACT Indoor humidity
Yuechao Chao, Junwei Liu, Zhihua Zhou, Yahui Du, Hailu Wei, Haibin Yang, Xueqing Yang, Cheng Wang, Zhenzhong Zeng, Hongzhi Cui, Jinyue Yan   +10 more
wiley   +1 more source

Electromagnetic control and heat transfer enhancement in exothermic reactions experiencing current density: The study preventing thermal explosions in reactive flow

Applied Rheology
Thermal explosions in reactive flows present an important risk to industrial engineering systems, where uncontrolled exothermic reactions can compromise safety and operational integrity.
Gasmi Hatem, Akindele Akintayo Oladimeji, Obalalu Adebowale Martins, Usman Abdulazeez Adebayo, Khan Umair, Yilmaz Yalcin, Taiwo Musilimu, Hussain Syed Modassir, Nizampatnam Neelima   +8 more
doaj   +1 more source

Analysis of Thermal Stability in a Convecting and Radiating Two-Step Reactive Slab

Advances in Mechanical Engineering, 2013
This paper investigates the combined effects of convective and radiative heat loss on thermal stability of a rectangular slab of combustible materials with internal heat generation due to a two-step exothermic chemical reaction, taking the diffusion of ...
O. D. Makinde, M. S. Tshehla
doaj   +1 more source

Interfacial Water Coordination on Ruthenium Oxide Nanoparticles Confined Within Covalent Organic Framework and Its Effect on Electrochemical Nitrate Reduction

Advanced Science, EarlyView.
We demonstrate how oxygen‐deficient ruthenium oxide (RuOx) nanoparticles confined within covalent organic framework achieve highly efficient nitrate‐to‐ammonia conversion. Strong interaction between RuOx nanoparticles and COF results in modified interfacial hydrogen‐bond water network and adsorption of nitrogenous intermediates.
Yun Li, Xin Zhao, Arsenii S. Portniagin, Yuxuan Wu, Desui Chen, Haochen Liu, Andrey L. Rogach   +6 more
wiley   +1 more source

Experimental Investigation of Infrared Detection of Debonding in Concrete-Filled Steel Tubes via Cooling-Based Excitation

Buildings
Debonding in concrete-filled steel tubes (CFSTs) is a common defect that often occurs during the construction phase of CFST structures, significantly reducing their load-bearing capacity.
Haonan Cai, Chongsheng Cheng
doaj   +1 more source