A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity. [PDF]
PLoS ONE, 2016 Many bacterial and viral pathogens (or their toxins), including Pseudomonas aeruginosa exotoxin A, require processing by host pro-protein convertases such as furin to cause disease.
Timothy E G Ferguson +4 more
doaj +4 more sources
Preparation and evaluation of the exotoxin A nano-gold conjugate as a vaccine candidate for Pseudomonas aeruginosa infections [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Pseudomonas aeruginosa is an opportunistic pathogen that is an important cause of nosocomial infections. This bacterium produces various virulence factors, among which exotoxin A is significantly involved in mortality and morbidity. In this
Masoumeh Abbasi +4 more
doaj +1 more source
Clostridium perfringens-Induced Necrotic Diseases: An Overview
Immuno, 2022 Clostridium perfringens, a prevalent Gram-positive bacterium, causes necrotic diseases associated with abundant life loss and economic burdens of billions of USD. The mechanism of C. perfringens-induced necrotic diseases remains largely unknown, in part,
Ying Fu, Tahrir Alenezi, Xiaolun Sun
doaj +1 more source
Streptococcus pyogenes strains associated with invasive and non-invasive infections present possible links with emm types and superantigens [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Streptococcus pyogenes, a notorious human pathogen is responsible to cause a wide range of infections varies from superficial common clinical illness to severe and life threatening infections.
Rao Muhammad Abid Khan +2 more
doaj +1 more source
Host Cationic Antimicrobial Molecules Inhibit S. aureus Exotoxin Production
mSphere, 2023 Innate immune molecules, including antimicrobial peptides (for example, defensins) and lysozyme, function to delay or prevent bacterial infections. These molecules are commonly found on mucosal and skin surfaces.
Patrick M. Schlievert +5 more
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Periodontology 2000, EarlyView., 2023 Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis +5 more
wiley +1 more source
Pseudomonas aeruginosa: Prevalence of Pathogenic Genes, OprL and ToxA in Human and Veterinary Clinical Samples in Ardabil, Iran, 2020 [PDF]
Journal of Advanced Biomedical Sciences, 2022 Background & Objective: An opportunistic pathogen Pseudomonas aeruginosa can cause frequent hospital-acquired infections as well as one microorganism in the food spoilage. Also, the emergence of multidrug-resistant P.
Ciamak Ghazaei
doaj
AMB Express, 2021 This work explores the ADP-ribosyltransferase activity of Pseudomonas (P.) aeruginosa exotoxin A using the guanyl hydrazone derivative, nitrobenzylidine aminoguanidine (NBAG) and the impact of gamma radiation on its efficacy.
Radwa N. Morgan +3 more
doaj +1 more source
mSystems, 2021 Clonal replacement is a major driver for changes in bacterial disease epidemiology. Recently, it has been proposed that episodic emergence of novel, hypervirulent clones of group A Streptococcus (GAS) results from acquisition of a 36-kb DNA region ...
Sruti DebRoy +11 more
doaj +1 more source
Crystal Structure of Exotoxin A from Aeromonas Pathogenic Species
Toxins, 2020 Aeromonas exotoxin A (AE) is a bacterial virulence factor recently discovered in a clinical case of necrotising fasciitis caused by the flesh-eating Aeromonas hydrophila.
Geoffrey Masuyer
doaj +1 more source