Results 51 to 60 of about 103,842 (257)

Certification of a pharmacopoeial reference standard for potency testing of recombinant interferon α-2b

Биопрепараты: Профилактика, диагностика, лечение
SCIENTIFIC RELEVANCE. Potency testing of recombinant interferons requires a reference standard. The availability of International Standards (ISs) that are commonly used to assess the quality of recombinant interferons is currently limited. Therefore, the
L. A. Gaiderova, Yu. N. Lebedeva, T. N. Lobanova, E. K. Lipatova, R. A. Volkova, O. V. Fadeikina   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Evaluation for the Measurement Uncertainty of Radiation Launch Field Strength

机车电传动, 2010
All measurement results were inevitable with uncertainty. This paper introduced the evaluation method and calculation for the measurement uncertainty of radiation launch field strength, the electromagnetic compatibility laboratory of the National ...
王益民, 余定华, 蔡万银
doaj  

Requirements for the information on reference standards submitted in the dossier for biologicals

Биопрепараты: Профилактика, диагностика, лечение
SCIENTIFIC RELEVANCE. The use of appropriately certified reference standards (RSs) is a necessary element of analytical procedure standardisation that ensures comparability of results across different laboratories assessing the quality of medicines ...
R. A. Volkova, O. V. Fadeikina, O. B. Ustinnikova, K. A. Sarkisyan, A. A. Movsesyants, V. A. Merkulov, V. V. Kosenko   +6 more
doaj   +1 more source

Expanding Uncertainty Principle To Certainty-Uncertainty Principles With Neutrosophy And Quad-Stage Method

Neutrosophic Sets and Systems, 2015
The most famous contribution of Heisenberg is uncertainty principle. But the original uncertainty principle is improper. Considering all the possible situations (including the case that people can create laws) and applying Neutrosophy and Quad-stage Method, this paper presents "certainty-uncertainty principles" with general form and variable dimension ...
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Expanding a dictionary of marker words for uncertainty and negation using distributional semantics [PDF]

Proceedings of the Sixth International Workshop on Health Text Mining and Information Analysis, 2015
Approaches to determining the factuality of diagnoses and findings in clinical text tend to rely on dictionaries of marker words for uncertainty and negation. Here, a method for semi-automatically expanding a dictionary of marker words using distributional semantics is presented and evaluated. It is shown that ranking candidates for inclusion according
Alyaa Alfalahi, Maria Skeppstedt, Rickard Ahlbom, Roza Baskalayci, Aron Henriksson, Lars Asker, Carita Paradis, Andreas Kerren   +7 more
openaire   +3 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Retention Time of Four Common Poisons （Drugs） by GC-MS Qualitative Analysis [PDF]

Fayixue Zazhi, 2018
Objective To investigate the maximum allowable deviation of retention time （RT） or relative retention time （RRT） between the common poisons （drugs） and standard solvent by gas chromatography-mass spectrometry （GC-MS）.
LIU Shao-dan, MIN Tao, WANG Mei，et al.
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source