Results 151 to 160 of about 2,429,010 (293)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Unified long-read panel for Parkinson's and repeat expansion disorders. [PDF]

NPJ Parkinsons Dis
Fienemann A, Prietzsche JC, Laβ J, Much C, Schaake S, Lüth T, Gabbert C, Zimprich A, Stögmann E, König T, Ganos C, Gül-Demirkale T, Başak AN, Jamora RDG, Rosales RL, Saranza G, Diesta CCE, Möller M, Borsche M, Kleinz T, Balck A, Brüggemann N, Seibler P, Klein C, Trinh J.   +24 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Skeletal displacements and upper airway changes following tooth-borne and tooth-bone-borne rapid palatal expansion in adolescents: secondary analysis of a randomized clinical trial. [PDF]

BMC Oral Health
Giap HV, Alomaym M, Chung CJ, Choi SH, Chun JH, Alkhamees A, Lee KJ.   +6 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Comparative Evaluation of Transverse Maxillary Arch Changes in Mixed Dentition with Clear Aligners vs Conventional Maxillary Expanders: A Systematic Review and Meta-analysis. [PDF]

Int J Clin Pediatr Dent
Athawale S, Mohelay N, Batra P, Talwar A, Singh AK.   +4 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Tissue-Specific Remodeling and Load Partitioning in Maxillary Expansion: An Evidence-Informed Three-Compartment Mechanobiological Framework. [PDF]

Bioengineering (Basel)
Hajduk G, Kuc P, Kuc N, Hajduk S, Sarul M, Kuc AE.   +5 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Synergistic Modification of Static Chemical Agent with Fly Ash and Hemihydrate Gypsum for Mechanically Compatible Gas Drainage Borehole Sealing. [PDF]

ACS Omega
Tang W, Zhai C, Xu J, Zheng Y, Zhang J, Fang X, Yan W.   +6 more
europepmc   +1 more source