Results 41 to 50 of about 100,607 (267)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

An After-Hours Virtual Care Service for Children With Medical Complexity and New Medical Technology: Mixed Methods Feasibility Study

JMIR Pediatrics and Parenting, 2023
BackgroundFamily caregivers (FCs) of children with medical complexity require specialized support to promote the safe management of new medical technologies (eg, gastrostomy tubes) during hospital-to-home transitions. With limited
Katherine Babayan, Krista Keilty, Jessica Esufali, Francisco J Grajales III   +3 more
doaj   +1 more source

Physics of notochord tube expansion in ascidians

Proceedings of the National Academy of Sciences
Interaction of cells and the surrounding lumen drives the formation of tubular system that plays the transport and exchange functions within an organism. The physical and biological mechanisms of lumen expansion have been explored. However, how cells communicate and coordinate with the surrounding lumen, leading to continuous tube expansion to a ...
Wenjie Shi, Charlie Duclut, Yan Xu, Yuanting Ma, Jinghan Qiao, Boyan Lin, Dongyu Yang, Jacques Prost, Bo Dong   +8 more
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Hot Gas Forming of Aluminum Alloy Tubes Using Flame Heating

Journal of Manufacturing and Materials Processing, 2020
Hot metal gas forming (HMGF) is a desirable way for the automotive industry to produce complex metallic parts with poor formability, such as aluminum alloys.
Ali Talebi-Anaraki, Mehdi Chougan, Mohsen Loh-Mousavi, Tomoyoshi Maeno   +3 more
doaj   +1 more source

Control of airway tube diameter and integrity by secreted chitin-binding proteins in Drosophila. [PDF]

PLoS ONE, 2013
The transporting function of many branched tubular networks like our lungs and circulatory system depend on the sizes and shapes of their branches. Understanding the mechanisms of tube size control during organ development may offer new insights into a ...
Katarína Tiklová, Vasilios Tsarouhas, Christos Samakovlis   +2 more
doaj   +1 more source

Pollination, pollen tube growth, and fertilization independently contribute to fruit set and development in tomato

Frontiers in Plant Science, 2023
In flowering plants, pollination, pollen tube growth, and fertilization are regarded as the first hierarchical processes of producing offspring. However, their independent contributions to fruit set and development remain unclear.
Long T. Tran, Koichi Sugimoto, Koichi Sugimoto, Michael Kasozi, Oscar W. Mitalo, Hiroshi Ezura, Hiroshi Ezura   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Optimisation of Aluminium Alloy Variable Diameter Tubes Hydroforming Process Based on Machine Learning

Applied Sciences
To predict the forming behaviour of aluminium alloy variable diameter tubes during hydroforming, a genetic algorithm-enhanced particle swarm optimisation (GA-PSO) is used to optimise a backpropagation neural network (BP-NN). A fast prediction model based
Yong Xu, Xuewei Zhang, Wenlong Xie, Shihong Zhang, Yaqiang Tian, Liansheng Chen   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source