Results 91 to 100 of about 289,533 (294)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Editorial: Placebo and Nocebo Effects in Psychiatry and Beyond

open access: yesFrontiers in Psychiatry, 2020
Katja Weimer   +8 more
doaj   +1 more source

Expectancy-Violation and Information-Theoretic Models of Melodic Complexity

open access: yesEmpirical Musicology Review, 2016
The present study assesses two types of models for melodic complexity: one based on expectancy violations and the other one related to an information-theoretic account of redundancy in music.
Tuomas Eerola
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Life expectancy for community‐dwelling persons with dementia and severe disability

open access: green, 2022
Krista L. Harrison   +6 more
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

The Probation Period for Debutant Civil Servants. Influencing Expectancy

open access: yesTransylvanian Review of Administrative Sciences, 2012
This study is part of a broader research on work motivation in the Romanian local public administration, based on Vroom’s motivational model. The research has tried to diagnose Romanian local public institutions (city halls in particular) regarding the ...
Leonina Emilia SUCIU   +2 more
doaj  

Methodological Approach to Assessing the Working Life Expectancy of the Population in a Region

open access: gold, 2022
Olga Kozlova   +3 more
openalex   +1 more source

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