Results 141 to 150 of about 536,569 (368)

Expecting the Unexpected

open access: yesSSRN Electronic Journal, 2015
If the patentee’s invention produced unexpected results, the law says, thatis pretty good evidence that it wasn’t obvious. But the law also says thatif it is obvious to try to make something, and if those who might try wouldexpect to succeed, making that thing is not patentable. It’s just theordinary work we expect of scientists.These two doctrines can
openaire   +4 more sources

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

open access: yesMolecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang   +3 more
wiley   +1 more source

Placebos as a Source of Agency: Evidence and Implications

open access: yesFrontiers in Psychiatry, 2019
Bioethical discussions surrounding the use of placebos in clinical practice have long revolved around the moral permissibility of deceiving a patient if it is likely to benefit them.
Phoebe Friesen
doaj   +1 more source

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

open access: yesMolecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa   +13 more
wiley   +1 more source

Rhythmic Effects of Syntax Processing in Music and Language

open access: yesFrontiers in Psychology, 2015
Music and language are human cognitive and neural functions that share many structural similarities. Past theories posit a sharing of neural resources between syntax processing in music and language (Patel, 2003), and a dynamic attention network that ...
Harim eJung   +3 more
doaj   +1 more source

Predicting the Path of an Open System [PDF]

open access: yesarXiv, 2006
The expected path of an open system,which is a big Poincare system,has been found in this paper.This path has been obtained from the actual and from the expected droop of the open system.The actual droop has been reconstructed from the variations in the power and in the frequency of the open system.The expected droop has been found as a function of ...
arxiv  

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

open access: yesMolecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock   +10 more
wiley   +1 more source

Jensen's inequality for conditional expectations [PDF]

open access: yesJ. Inequal. Pure and Appl. Math., 6(5), Art. 133, 2005, 2006
We study conditional expectations generated by an abelian $ C^* $-subalgebra in the centralizer of a positive functional. We formulate and prove Jensen's inequality for functions of several variables with respect to this type of conditional expectations, and we obtain as a corollary Jensen's inequality for expectation values.
arxiv  

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