Results 171 to 180 of about 536,569 (368)
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
ReligionsThis article explores the question, ‘What is distinctive about doing theology as an evangelical?’ It takes an autoethnographic approach, recounting how this practical theologian has wrestled with how evangelical conviction should shape the stance for ...
Sarah Lynn Bowers Dunlop
doaj +1 more source
Increased Life Expectancy After Aorta to Coronary Grafts [PDF]
, 1972 William H. Sewell
openalex +1 more source
Molecular Oncology, EarlyView.CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan +6 more
wiley +1 more source
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Derivative Preserving Conditions in Conditional Expectation Operator [PDF]
arXivIn this paper, we consider conditions that a higher order derivative preserve in conditional expectation operator for a generic nonlinear random variable. Also, the paper introduces higher order derivatives of the Expected Shortfall for a generic nonlinear portfolio loss random variable.
arxiv
Expectancy and frequency effects on perceptual and motor systems in choice reaction time [PDF]
, 1981 Jeff Miller, Ran D. Anbar
openalex +1 more source
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Editorial: Placebo and Nocebo Effects in Psychiatry and Beyond
Frontiers in Psychiatry, 2020 Katja Weimer +8 more
doaj +1 more source