Results 71 to 80 of about 320,450 (298)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Temporal expectancies driven by self- and externally generated rhythms [PDF]

, 2017
The dynamic attending theory proposes that rhythms entrain periodic fluctuations of attention which modulate the gain of sensory input. However, temporal expectancies can also be driven by the mere passage of time (foreperiod effect).
Granjon, Lionel, Hsu, Yi-Fang, Jones, Alexander, Waszak, Florian   +3 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Demographic Change, Social Security Systems, and Savings [PDF]

In theory, improvements in healthy life expectancy should generate increases in the average age of retirement, with little effect on savings rates. In many countries, however, retirement incentives in social security programs prevent retirement ages from
David Canning, David E. Bloom, Michael Moore, Rick Mansfield   +3 more
core   +3 more sources

Exploring the influence of expectancy, valence, and instrumentality on VR tourism intention: A framework based on TAM and expectancy theory

Acta Psychologica
Background: Virtual Reality (VR) has demonstrated tremendous potential to transform the tourism industry, offering tourists immersive experiences in remote destinations with reduced costs.
Tong Zhang, Shaowei Xiong
doaj   +1 more source

The Effect of the Theory of Acceptance and Use of Augmented Reality on the Intention to Use Mobile Tourism Augmented Reality Apps: the Mediating Role of Hedonic Motivation [PDF]

International Journal of Digital Content Management
Purpose: In contemporary times, augmented reality is a cornerstone technology within the tourism sector. Nonetheless, the inclination towards embracing and utilizing augmented reality applications in tourism hinges upon multifaceted determinants ...
Payam Partovinia, Niloofar Abbaspoor
doaj   +1 more source

Starfished in the sand : developing the theory of planned behaviour to predict intentions to use sunscreen on the beach : a research project presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University, Albany, Auckland, New Zealand [PDF]

, 2003
This study examined the predictive power of the theory of planned behaviour in explaining sunscreen use intentions among beach-goers in New Zealand (n = 148) and the United Kingdom (n = 280). Generally, the theory of planned behaviour performed well with
Neil, Tessa Anne
core  

Towards the integration of culture into the Unified Theory of Acceptance and Use of Technology [PDF]

, 2012
Educational technology is increasingly used in multicultural contexts and across national cultures. Educational technology users with different national and professional backgrounds may, however, exhibit different attitudes towards technology.
Ceobanu, Ciprian, Heymann, Jan Oliver, Lerche, Thomas, Nistor, Nicolae, Weinberger, Armin   +4 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source