Results 81 to 90 of about 826,810 (310)

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti   +8 more
wiley   +1 more source

Necessity of eigenstate thermalization for equilibration towards unique expectation values when starting from generic initial states [PDF]

open access: yes, 2017
We investigate dynamical equilibration of expectation values in closed quantum systems for realistic non-equilibrium initial states. Thereby we find that the corresponding long time expectation values depend on the initial expectation values if eigenstate thermalization is violated.
arxiv   +1 more source

Rational Expectations and the Theory of Economic Policy

open access: yesJournal of Monetary Economics, 1974
There is no longer any serious debate about whether monetary policy should be conducted according to rules or discretion. Quite appropriately, it is widely agreed that monetary policy should obey a rule, that is, a schedule expressing the setting of the monetary authority’s instrument (e.g., the money supply) as a function of all the information it has
Thomas J. Sargent, Neil Wallace
openaire   +4 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Sublinear expectation linear regression [PDF]

open access: yesarXiv, 2013
Nonlinear expectation, including sublinear expectation as its special case, is a new and original framework of probability theory and has potential applications in some scientific fields, especially in finance risk measure and management. Under the nonlinear expectation framework, however, the related statistical models and statistical inferences have ...
arxiv  

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

open access: yesMolecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric   +11 more
wiley   +1 more source

Expected Supremum of a Random Linear Combination of Shifted Kernels [PDF]

open access: yesarXiv, 2012
We address the expected supremum of a linear combination of shifts of the sinc kernel with random coefficients. When the coefficients are Gaussian, the expected supremum is of order \sqrt{\log n}, where n is the number of shifts. When the coefficients are uniformly bounded, the expected supremum is of order \log\log n.
arxiv  

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