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Biochemistry and Molecular Biology Education, Volume 53, Issue 2, Page 209-217, March/April 2025.Abstract We created a novel laboratory experience where undergraduate students explore the techniques used to study protein misfolding, unfolding, and aggregation. Despite the importance of protein misfolding and aggregation diseases, protein unfolding is not typically explored in undergraduate biochemistry laboratory classes.
Alison Bates +2 more
wiley +1 more source
CDOs and Systematic Risk: Why bond ratings are inadequate [PDF]
This paper analyzes the risk properties of typical asset-backed securities (ABS), like CDOs or MBS, relying on a model with both macroeconomic and idiosyncratic components.
Christian Wilde, Jan Pieter Krahnen
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Biological Reviews, EarlyView.ABSTRACT Three categories of explanations exist for why we age: mechanistic theories, which omit reference to evolutionary forces; weakening force of selection theories, which posit that barriers exist that prevent evolutionary forces from optimising fitness in ageing; and optimisation theories, which posit that evolutionary forces actually select for ...
Michael S. Ringel
wiley +1 more source
Loss distributions in consumer credit risk : macroeconomic models for expected and unexpected loss
, 2016 This thesis focuses on modelling the distributions of loss in consumer credit arrangements, both at an individual level and at a portfolio level, and how these might be influenced by loan-specific factors and economic factors. The thesis primarily aims to examine how these factors can be incorporated into a credit risk model through logistic regression
openaire +2 more sources
Dynamic provisioning: rationale, functioning, and prudential treatment [PDF]
Current policy debate has renewed interest in countercyclical provisioning policies; dynamic provisions are regarded as a valuable device for pursuing this goal.
Emiliano Sabatini +3 more
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Macro stress testing with sector specific bankruptcy models [PDF]
, 2008 This paper employs the methodology of Wilson (1997) on Hungarian data to conduct a macro stress test in relation to banks' corporate loan portfolio. First, sector specific models of bankruptcy are estimated, where the bankruptcy frequency is linked to ...
Valentinyi-Endresz, Marianna +1 more
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The impact of urbanisation on social behaviour: a comprehensive review
Biological Reviews, EarlyView.ABSTRACT Urbanisation is a key driver of global environmental change and presents animals with novel stressors and challenges. It can fundamentally influence social behaviour and has the potential to reshape within‐ and between‐species social interactions. Given the role of social behaviour in reproductive fitness and survival, understanding how social
Avery L. Maune +2 more
wiley +1 more source
Information asymmetries and securitization design [PDF]
The strong growth in collateralized debt obligation transactions raises the question how these transactions are designed. The originator designs the transaction so as to maximize her benefit subject to requirements imposed by investors and rating ...
Günter Franke +2 more
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Loss Given Default Modelling: Comparative Analysis [PDF]
, 2013 In this study we investigated several most popular Loss Given Default (LGD) models (LSM, Tobit, Three-Tiered Tobit, Beta Regression, Inflated Beta Regression, Censored Gamma Regression) in order to compare their performance.
Yashkir, Olga, Yashkir, Yuriy
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Early evolutionary history of the seed
Biological Reviews, EarlyView.ABSTRACT The seed is an essential stage in the life history of gymnospermous and angiospermous plants, facilitating both their survival and dispersal. We reappraise knowledge of the evolutionary history of the gymnospermous seed, from its origin in the late Devonian through to the well‐known end‐Permian extinctions – an interval encompassing the ...
Richard M. Bateman +2 more
wiley +1 more source