Results 71 to 80 of about 1,032,768 (266)
A general theory of intertemporal decision-making and the perception of time
Frontiers in Behavioral Neuroscience, 2014 Animals and humans make decisions based on their expected outcomes. Since relevant outcomes are often delayed, perceiving delays and choosing between earlier versus later rewards (intertemporal decision-making) is an essential component of animal ...
Vijay Mohan eK Namboodiri +3 more
doaj +1 more source
Expected-Cover and Linear-Utility Tolerance Intervals
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1966 Summary Expected-cover tolerance intervals are commonly used as a means of statistical prediction. In their construction the effectiveness of such intervals in relation to a future observation y is assessed only in terms of “success” if y falls in the interval and of “failure” otherwise; no account is taken in the assessment of how far ...
openaire +2 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
E3S Web of Conferences, 2016 In the present paper on the basis of a probabilistic interpretation of the earthquake repetition law, simple formulas were obtained which allow us from the known number of earthquake events in a representative interval of energy class (magnitude) to ...
Bogdanov Vadim, Pavlov Aleksey
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
EpidemicsGeneration intervals are distributions that describe the time between infection and onward transmission. They are a key epidemiological quantity because, together with the reproduction number R, they determine the population-level growth rate r of a ...
Yeongseon Park, Katia Koelle
doaj +1 more source
Optimum Energy Management in Smart Grids Based on Power Pinch Analysis
Chemical Engineering Transactions, 2014 This work proposes a systemic approach to identify optimum power management strategies (PMS) in renewable energy smart-grids by using the Power Grand Composite Curves (PGCC) approach to adaptively adjust the system operation in short-term power ...
D. Giaouris +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source